Synthesis and structures of ferrocenyl-substituted salicylaldiminato complexes of magnesium, titanium and zirconium

Bott, Robyn K. J.; Schormann, Mark; Hughes, David L.; Lancaster, Simon; Bochmann, Manfred

doi:10.1016/j.poly.2005.07.012

Cited by 21 publications

(20 citation statements)

References 27 publications

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“…Tang et al have reported that titanium (IV) catalysts bearing phenoxyimine ligand with side‐arm, i.e., [O − NP], [O − NO], or [O − NS] tridentate ligands, were robust and highly active for ethylene homo‐ and copolymerization with linear α‐olefin and cycloolefin, and so forth 15–19. Qian and coworkers20–22 and Lancaster and coworkers23, 24 reported the synthesis of half‐titanocenes containing phenoxyimine ligands and their use as catalysts for olefin polymerization. Recently, Jin and coworkers25 reported the synthesis of titanium complexes with monocyclopentadienyl and tridentate aryloxide or arylsulfide and their use as catalysts in ethylene polymerization.…”

Section: Introductionmentioning

confidence: 99%

Treatment of core‐binding‐factor in acute myelogenous leukemia with fludarabine, cytarabine, and granulocyte colony‐stimulating factor results in improved event‐free survival

Borthakur

Kantarjian

Wang

et al. 2008

Cancer

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Background Acute myelogenous leukemia (AML) associated with core binding factor abnormalities (CBF) is the type of leukemia most responsive to cytarabine (ara-C) therapy and is of relative favorable prognosis. In vitro and ex vivo observations suggest that increases in intra-cellular ara-C levels influenced by administration of fludarabine and granulocyte colony stimulating factor (GCSF) increase the effect of ara-C; prompting us to clinically evaluate the efficacy of such combinations. Methods We analyzed the event free survival of patients with newly diagnosed CBF AML treated with fludarabine and ara-C (FA) (N=45) or with FA and GCSF (FLAG)(N=22) and compared results to patients treated with regimens consisting of idarubicin and ara-C with or without GCSF (IA/IAG)(N=47). Results We demonstrate that after accounting for prognostic covariates other than treatment (including year in which treatment was administered); FA, and in particular FLAG, were associated with longer event free survival (EFS) than IA/IAG. Conclusion Thus our data lends clinical credence to the observed modulation of ara-C by fludarabine and G-CSF.

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Section: Introductionmentioning

confidence: 99%

Treatment of core‐binding‐factor in acute myelogenous leukemia with fludarabine, cytarabine, and granulocyte colony‐stimulating factor results in improved event‐free survival

Borthakur

Kantarjian

Wang

et al. 2008

Cancer

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“…The closest structural analogue to 2 is likely to be the ferrocenyl‐substituted (salicylaldiminato)magnesium complex of Lancaster and Bochmann et al, where N,O‐chelation occurs at two sites around the magnesium atom. In this case, however, the magnesium atom is six‐coordinate by bonding to two THF molecules 8. It is likely that the increased steric bulk of 2 L prevents the octahedral geometry from occurring in 2 .…”

Section: Resultsmentioning

confidence: 95%

“…Comparatively, few studies have focused on the systematic investigation of steric effects on the structures of bis(salicylaldiminato)magnesium complexes. Bochmann and Lancaster reported a ferrocenyl‐substituted (salicylaldminato)magnesium complex as an octahedral structure composed of two bidentate ligands and two THF solvent molecules 8…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Structural Characterization of Bis(salicylaldiminato)magnesium Complexes of Varying Aggregation and Coordination State

2011

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A series of salicylaldiminato ligands [C6H5N=CHC6H4OH (1L), 2,6‐iPrC6H3N=CHC6H4OH (2L), and 2,6‐iPrC6H3N=CH‐3,5‐tBu2C6H2OH (3L)] were treated with Bu2Mg in the presence of the appropriate solvent system to yield the crystalline compounds [(1L6Mg3)·thf] (1), [(2L2Mg·thf)] (2), and [3L2Mg] (3). The products were characterized by 1H and 13C NMR spectroscopy and single‐crystal X‐ray diffraction. X‐ray crystallographic analysis revealed that 1 adopts a unique trimeric aggregation state consisting of six‐coordinate magnesium centers. Substitution of the ligand backbone resulted in the formation of the monomeric species 2 and 3. X‐ray crystallographic analyses revealed 2 as a five‐coordinate, distorted square‐pyramidal magnesium complex and 3 as a four‐coordinate, distorted tetrahedral species. Inspection of the metrical parameters in 1–3 indicates a decrease in the Mg–O and Mg–N bond lengths and an increase in the N–Mg–O bite angle with a decreasing coordination number at magnesium.

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“…According to the coordinated THF positions of related magnesium complexes in the literature [46][47][48], the cis-configuration for 1 is observed (OTHF-Mg-OTHF, 87.62(4)°). The Mg-OTHF bond length of 1 (2.1516(8) Å) is longer than those found in cis-form (2.0661(10)-2.136(5) Å) [46][47][48]. The Mg-Nindolyl bond lengths (2.1067(9) Å) are close to those found in magnesium bis-indolyl complexes (2.0907(16) Å for trans-form; 2.126(2) and 2.138(2) Å for cis-form) [28].…”

Section: Scheme 1 Synthetic Routes For Ligand Precursors and Magnesimentioning

confidence: 92%

Magnesium Pyrazolyl-Indolyl Complexes as Catalysts for Ring-Opening Polymerization of L-Lactide

Chen¹,

Lin²,

Peng³

2015

Polymers

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A series indole-based ligand precursors, Pz R IndH (R = H, Pz H IndH; R = Me, Pz Me IndH; R = t-Bu, Pz tBu IndH; and R = Ph, Pz Ph IndH), have been synthesized via copper-catalyzed N-arylation (for Pz H IndH) or the Bartoli indole synthesis (for Pz Me IndH, Pz tBu IndH and Pz Ph IndH) reactions with moderate to high yield. Reactions of these ligand precursors with 0.7 equivalent of Mg n Bu 2 in THF (for 1) or hexane (for 2-4) afforded the bis-indolyl magnesium complexes 1-4, respectively. All the ligand precursors and related magnesium complexes have been characterized by NMR spectroscopy and elemental analyses. The molecular structure is reported for compound 1.These novel magnesium complexes demonstrate efficient catalytic activities for the ring-opening polymerization of L-lactide in the presence of alcohol.

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Synthesis and structures of ferrocenyl-substituted salicylaldiminato complexes of magnesium, titanium and zirconium

Cited by 21 publications

References 27 publications

Treatment of core‐binding‐factor in acute myelogenous leukemia with fludarabine, cytarabine, and granulocyte colony‐stimulating factor results in improved event‐free survival

Treatment of core‐binding‐factor in acute myelogenous leukemia with fludarabine, cytarabine, and granulocyte colony‐stimulating factor results in improved event‐free survival

Synthesis and Structural Characterization of Bis(salicylaldiminato)magnesium Complexes of Varying Aggregation and Coordination State

Magnesium Pyrazolyl-Indolyl Complexes as Catalysts for Ring-Opening Polymerization of L-Lactide

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