Synthesis and study antimicrobial activities of some novel Tetrazole derivatives

Nessim, M.I.; Elewa, Safaa I.; Mohamed, Manal G.

doi:10.21608/ejchem.2018.2214.1178

Cited by 2 publications

(4 citation statements)

References 27 publications

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“…S4. 1 A mixture of S 2 0.204 g (0.001 mol) was reacted with 0.001 mol of appropriate aldehyde (2-thiophenecarboxy aldehyde, 4-bromobenzaldehyde). A quantity of 2-3 drops of glacial acetic acid was added to the reactants.…”

Section: Synthesis Of Ethyl 4-(1h-tetrazol-1-yl) Benzohydrazide (S 2 )mentioning

confidence: 99%

“…S13. 1 H-NMR (500 MHz, DMSO-d 6 , δ/ppm): 7.68-7.61 (m, 5H, aromatic proton) 4.29 (s, 2H, SCH 2 ), 4.13 (q, J = 7.1 Hz, 2H, OCH 2 ), 1.18 (t, J = 7.1 Hz, 3H, CH 2 CH 3 ) Fig. S14.…”

Section: Synthesis Of Ethyl [(1-phenyl-1h-tetrazol-5-yl) Sulfanyl] Ac...mentioning

confidence: 99%

“…This compound is a solid material with white to light yellow color crystals and a faint odor. It is soluble in water and alcohol solvents [1].…”

Section: ■ Introductionmentioning

confidence: 99%

“…Tetrazole derivatives have highly beneficial pharmacological and biological properties. They have been reported to exhibit a wide range of biological activities [2] such as analgesic activity [3][4], antifungal [5][6][7][8], antimicrobial [1,[9][10], anti-inflammatory [8,11], antiviral [12], antihypertensive [13], anticancer [2,[14][15], and anti-HIV [16]. The utility of the tetrazole ring in the applications of medicinal chemistry is due to its isosteric properties.…”

Section: ■ Introductionmentioning

confidence: 99%

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Synthesis, Characterization and Antioxidant Evaluation of Some Tetrazole Derivatives

Dalal

Mekky²

2022

Indones. J. Chem.

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The present study introduces the synthesis of two series of tetrazole derivatives. Firstly, monosubstituted S1 was prepared by the reaction of ethyl 4-aminobenzoate with an amount of sodium azide and triethyl orthoformate in hot glacial acetic acid. Then, ethyl 4-(1H-tetrazol-1-yl) benzoate S1 was treated with a solution of hydrazine hydrate to prepare acetohydrazide S2. After that, tetrazole derivatives S3-S4 were prepared via the reaction of acetohydrazide S2 with various aromatic aldehydes. Secondly, compound 1,5-disubstituted tetrazole S5 was prepared from the reaction of aryl isothiocyanate with sodium azide in water presence. Then alkylation to compound S5 was made with ethyl chloroacetate to produce S6. In the next step, S6 was reacted with hydrazine hydrate to get acetohydrazide S7. Moreover, the produced S7 was reacted with some aromatic aldehydes for the synthesis of S8-S10. The structures of synthesized compounds were confirmed by the different available spectral methods, i.e., FTIR, 1H-NMR and 13C-NMR spectroscopy. The antioxidant activity of the synthesized compounds was evaluated by the use of 2,2-diphenyl-1-picrylhydrazyl. The results showed that compound S10 has the highest value as radical scavenging among the synthesized compounds.

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Section: Synthesis Of Ethyl 4-(1h-tetrazol-1-yl) Benzohydrazide (S 2 )mentioning

confidence: 99%

“…S13. 1 H-NMR (500 MHz, DMSO-d 6 , δ/ppm): 7.68-7.61 (m, 5H, aromatic proton) 4.29 (s, 2H, SCH 2 ), 4.13 (q, J = 7.1 Hz, 2H, OCH 2 ), 1.18 (t, J = 7.1 Hz, 3H, CH 2 CH 3 ) Fig. S14.…”

Section: Synthesis Of Ethyl [(1-phenyl-1h-tetrazol-5-yl) Sulfanyl] Ac...mentioning

confidence: 99%

“…This compound is a solid material with white to light yellow color crystals and a faint odor. It is soluble in water and alcohol solvents [1].…”

Section: ■ Introductionmentioning

confidence: 99%

Section: ■ Introductionmentioning

confidence: 99%

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Synthesis, Characterization and Antioxidant Evaluation of Some Tetrazole Derivatives

Dalal

Mekky²

2022

Indones. J. Chem.

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A review on synthesis of nitrogen-containing heterocyclic dyes for textile fibers - Part 2: Fused heterocycles

Khattab

Rehan

2018

Egypt. J. Chem.

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I MPORTANCE of heterocyclic dyes has recently increased due to their deep shades, high tentorial strength, excellent colorfastness and brightness compared to azobenzene analogous. Development of novel synthetic approaches for fused heterocyclic dyes has remained a highly interesting but challenging proposition. An overview of the application of nitrogen-containing fused heterocyclic dyestuffs for textile coloration is presented. In this review, we provide details outlining the synthesis of recently prepared fused nitrogen-containing heterocyclic dyestuffs and their dyeing efficiency on textile fibers.

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Synthesis and study antimicrobial activities of some novel Tetrazole derivatives

Cited by 2 publications

References 27 publications

Synthesis, Characterization and Antioxidant Evaluation of Some Tetrazole Derivatives

Synthesis, Characterization and Antioxidant Evaluation of Some Tetrazole Derivatives

A review on synthesis of nitrogen-containing heterocyclic dyes for textile fibers - Part 2: Fused heterocycles

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