Synthesis and study of antimicrobial activity of new tetralone esters

Hucchegowda, Krishna Mudeenahally; Basavaiah, Basavaraju Yeriyur; Umesha, Basavaiah; Basavaiah, Shivakumar Santhekasalagere

doi:10.5155/eurjchem.5.4.584-587.1093

Eur. J. Chem.

2014

DOI: 10.5155/eurjchem.5.4.584-587.1093

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Synthesis and study of antimicrobial activity of new tetralone esters

Krishna Mudeenahally Hucchegowda

Basavaraju Yeriyur Basavaiah

Basavaiah Umesha

et al.

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2024

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Regioselective Oxidation of Tetrahydronaphthalenes to α-Tetralone Derivatives Using DDQ as Oxidizing Agent: Synthesis and Evaluation of Antibacterial and Antifungal Activities

Meddeb,

Thebti,

Elleuch

et al. 2024

ACS Omega

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An easy and efficient approach for the synthesis of highly regioselective functionalized dihydronaphthalen-1(2H)-one family of α-tetralones from functionalized tetralone precursors which derived from Morita–Baylis–Hillman (MBH) adducts as starting substrates has been developed. The target dihydronaphthalen-1(2H)-ones are obtained through the oxidation of tetrahydronaphthalenes (THN) using DDQ as the oxidizing agent, conducted in aqueous acetic acid at reflux conditions. The yields obtained ranged from 90 to 98%. The resulting dihydronaphthalen-1(2H)-ones were evaluated for their in vitro antibacterial activity against nine Gram-positive and six Gram-negative strains. Additionally, their antifungal properties were assessed against three fungal pathogens by using the microdilution method and Biolog Phenotype Microarrays technology. Remarkably, the synthesized dihydronaphthalen-1(2H)-ones exhibited good antibacterial activity when compared to reference drugs such as vancomycin and ampicillin. Similarly, their antifungal activity is comparable to the effectiveness of the reference drugs cycloheximide and fluconazole.

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Regioselective Oxidation of Tetrahydronaphthalenes to α-Tetralone Derivatives Using DDQ as Oxidizing Agent: Synthesis and Evaluation of Antibacterial and Antifungal Activities

Meddeb,

Thebti,

Elleuch

et al. 2024

ACS Omega

View full text Add to dashboard Cite

show abstract

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Synthesis and study of antimicrobial activity of new tetralone esters

Cited by 1 publication

References 14 publications

Regioselective Oxidation of Tetrahydronaphthalenes to α-Tetralone Derivatives Using DDQ as Oxidizing Agent: Synthesis and Evaluation of Antibacterial and Antifungal Activities

Regioselective Oxidation of Tetrahydronaphthalenes to α-Tetralone Derivatives Using DDQ as Oxidizing Agent: Synthesis and Evaluation of Antibacterial and Antifungal Activities

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