Synthesis and study of the cancer cell growth inhibitory properties of α-, γ-tocopheryl and γ-tocotrienyl 2-phenylselenyl succinates

Vraka, P.; Drouza, Chryssoula; Rikkou, Maria D.; Odysseos, Andreani; Keramidas, Anastasios D.

doi:10.1016/j.bmc.2005.11.045

Cited by 29 publications

(21 citation statements)

References 42 publications

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“…Based on the pharmacological findings [37,38] and the QSAR study results [16], was supposed that esterification of the lysine with g-tocotrienol could result in formation of novel compounds with enhanced anticancer activity.…”

Section: Resultsmentioning

confidence: 99%

“…Better antiproliferative and pro-apoptotic properties of tocotrienols than tocopherols [35,37] inspire us to design and examine novel tocotrienol derivatives. Tocotrienols have been shown to induce apoptosis by activating caspase-8 and caspase-3 in neoplastic mammary epithelial cells.…”

Section: Coefficientsmentioning

confidence: 99%

“…Based on the pharmacological findings [37,38] and the QSAR study results [16], was designed novel lysine-g-tocotrienol ester (D-1 and D-2, Fig. 4) and its antiproliferative activity was evaluated using the developed QSAR models.…”

Section: Coefficientsmentioning

confidence: 99%

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Design and QSAR study of analogs of γ-tocotrienol with enhanced antiproliferative activity against human breast cancer cells

Nikolic

Agababa

2009

Journal of Molecular Graphics and Modelling

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Section: Resultsmentioning

confidence: 99%

Section: Coefficientsmentioning

confidence: 99%

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Design and QSAR study of analogs of γ-tocotrienol with enhanced antiproliferative activity against human breast cancer cells

Nikolic

Agababa

2009

Journal of Molecular Graphics and Modelling

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“…In support of this, a study in transgenic mice indicated that selenium suppresses prostate cancer in an animal model when combined with a-TOH [79]. Interestingly, novel seleno-analogues of esters of vitamin E, such as atocopheryl-2-phenylselenyl succinate, showed higher effect than their parental counterparts [80].…”

Section: Anticancer Activity Of Vitamin E Analoguesmentioning

confidence: 96%

Vitamin E analogues as anticancer agents: Lessons from studies with α-tocopheryl succinate

Wang

Dong

Zhao

et al. 2006

Mol. Nutr. Food Res.

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The new millennium has witnessed considerable decrease in a number of previously fatal pathologies, largely due to the advancement in molecular medicine and modern approaches to treatment. In spite of this success, neoplastic disease remains a serious problem due to several reasons. These include an exceedingly high variability of cancer cells even within the same type of tumour. Cancer cells, albeit of clonal origin, mutate so that they escape established treatments, resulting in the fatal outcome of current therapies. Moreover, there are types of cancer, such as mesotheliomas, that cannot be treated at present. A novel group of clinically interesting anticancer drugs has been a recent focus in the literature that hold substantial promise as selective anticancer drugs. These compounds, epitomised by alpha-tocopheryl succinate, comprise redox-silent analogues of vitamin E that have been shown to suppress several types of cancer in animal models, including breast, colon and lung cancer as well as mesotheliomas and melanomas, while being nontoxic to normal cells and tissues. It is now proven that the strong anticancer effect of vitamin E analogues stems from their propensity to induce selective apoptosis in malignant cells. The results point to the novel group of vitamin E analogues as promising agents applicable to different types of tumours.

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“…Literature revealed that natural and synthetic esters of succinic acid had a wide range of applications like industrial, agrochemical and pharmaceutical [4][5][6][7]. Some of these are the treatment of HIV, tumours, as antiseptic agents, antioxidants, as enzyme inhibition, resolving the racemic mixtures and in the synthesis of bioactive compounds [8][9][10][11][12][13][14][15][16].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of antifungal and antibacterial activities of monoesters of succinic anhydride

Iqbal¹,

Baloch²,

Baloch³

2014

Bull. Chem. Soc. Eth.

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ABSTRACT. Monoester of succinic acid (1-29), synthesised and characterised at our laboratory, were investigated with reference to their antifungal and antibacterial activities. The results concluded that though almost all the compounds were bioactive but the degree of activity was dependent over the substituent attached to benzyl group and order of their bioactivity was iodo > chloro > methoxy > nitro substituted monoesters against the considered microbes.

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Synthesis and study of the cancer cell growth inhibitory properties of α-, γ-tocopheryl and γ-tocotrienyl 2-phenylselenyl succinates

Cited by 29 publications

References 42 publications

Design and QSAR study of analogs of γ-tocotrienol with enhanced antiproliferative activity against human breast cancer cells

Design and QSAR study of analogs of γ-tocotrienol with enhanced antiproliferative activity against human breast cancer cells

Vitamin E analogues as anticancer agents: Lessons from studies with α-tocopheryl succinate

Evaluation of antifungal and antibacterial activities of monoesters of succinic anhydride

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