Synthesis and <sup>1</sup>H NMR data assignment of 3-acetamido-4-amino-3,4-dihydro-2<i>H</i>-pyran-6-carboxylates and their acetyl-migrated isomers

The synthesis and characterization of compounds 7c and 8d, the 4(R)‐epimer impurities of zanamivir and laninamivir octanoate, were reported for the first time. Their structures were confirmed by NMR and MS and distinguished from their corresponding active pharmaceutical ingredient (API) by coupling constant in 1H NMR and HPLC spectra. This work is of great significance for the drug‐related substances analysis in zanamivir and laninamivir octanoate.

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Synthesis and characterization of 4(R)‐epimer impurities of zanamivir and laninamivir octanoate

Duan

Liu

et al. 2021

Journal of Heterocyclic Chem

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Synthesis and ¹H NMR data assignment of 3-acetamido-4-amino-3,4-dihydro-2H-pyran-6-carboxylates and their acetyl-migrated isomers

Cited by 1 publication

References 7 publications

Synthesis and characterization of 4(R)‐epimer impurities of zanamivir and laninamivir octanoate

Synthesis and characterization of 4(R)‐epimer impurities of zanamivir and laninamivir octanoate

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Synthesis and 1H NMR data assignment of 3-acetamido-4-amino-3,4-dihydro-2H-pyran-6-carboxylates and their acetyl-migrated isomers

Cited by 1 publication

References 7 publications

Synthesis and characterization of 4(R)‐epimer impurities of zanamivir and laninamivir octanoate

Synthesis and characterization of 4(R)‐epimer impurities of zanamivir and laninamivir octanoate

Contact Info

Product

Resources

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Synthesis and ¹H NMR data assignment of 3-acetamido-4-amino-3,4-dihydro-2H-pyran-6-carboxylates and their acetyl-migrated isomers