Synthesis and surface modification of polyurethanes with chitosan for antibacterial properties

Kara, Filiz; Aksoy, Eda Ayşe; Yuksekdag, Zehra Nur; Hasırcı, Nesrin; Aksoy, Serpi̇l

doi:10.1016/j.carbpol.2014.05.019

Cited by 148 publications

(102 citation statements)

References 54 publications

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“…In contrast, the blank PVC film after irradiation has a rough surface (Rq = 17.3). UV irradiation may have led to bond breakage within polymeric chains and hence the removal of leachable constituents from the PVC surface which can result in a roughened surface [43]. Irradiation of PVC in the absence of photostabilizers could lead to dehydrochlorination which is common at 150 °C and above [44].…”

Section: Suggested Mechanisms Of Photostabilization Of Pvcmentioning

confidence: 99%

Photostabilizing Efficiency of Poly(vinyl chloride) in the Presence of Organotin(IV) Complexes as Photostabilizers

2016

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Three organotin complexes containing furosemide as a ligand (L), Ph 3 SnL, Me 2 SnL 2 and Bu 2 SnL 2 , were synthesized and characterized. Octahedral geometry was proposed for the Me 2 SnL 2 and Bu 2 SnL 2 , while the Ph 3 SnL complex has trigonal bipyramid geometry. The synthesized organotin complexes (0.5% by weight) were used as additives to improve the photostability of poly(vinyl chloride), PVC, (40 µm thickness) upon irradiation. The changes imposed on functional groups, weight loss and viscosity average molecular weight of PVC films were monitored. The experimental results show that the rate of photodegradation was reduced in the presence of the organotin additives. The quantum yield of the chain scission was found to be low (9.8 × 10 −7 ) when Ph 3 SnL was used as a PVC photostabilizer compared to controlled PVC (5.18 × 10 −6 ). In addition, the atomic force microscope images for the PVC films containing Ph 3 SnL 2 after irradiation shows a smooth surface compared to the controlled films. The rate of PVC photostabilization was found to be highest for Ph 3 SnL followed by Bu 2 SnL 2 and Me 2 SnL 2 . It has been suggested that the organotin complexes could act as hydrogen chloride scavengers, ultraviolet absorbers, peroxide decomposers and/or radical scavengers.

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Section: Suggested Mechanisms Of Photostabilization Of Pvcmentioning

confidence: 99%

Photostabilizing Efficiency of Poly(vinyl chloride) in the Presence of Organotin(IV) Complexes as Photostabilizers

2016

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“…This suggests that the electrostatic repulsion between neighboring particles were intense enough to yield a stable solution. Achieving stable, positively-charged CS nanoparticles is particularly important in drug delivery applications and cell-polymer interactions, where the cell membrane is often negatively charged [28].…”

Section: Resultsmentioning

confidence: 99%

Highly Monodisperse Chitosan Nanoparticles Prepared by a Combined Triple-Method for Potential Use as Drug Carriers

Sadeghi¹

2017

Int J Nanomater Nanotechnol Nanomed

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Chitosan (CS) as a biodegradable polymer with unique bio-attachment properties that makes it favorable to be used in biomedical applications. Insolubility in water is the problem with use of CS. The purpose of this study was to prepare low molecular weight, water-soluble CS nanoparticles that exhibit excellent water solubility and biological, chemical, and physical functions. Oxidative degradation technique using hydrogen peroxide (H 2 O 2 ) was used to decrease chitosan molecular weight. Then ultrasonication and ionic gelation method using sodium tripolyphosphate (TPP) were used to prepare CS nanoparticles. Molecular weight of chitosan determined by Ubbelohde viscometry and it decreased by approximately 100%. From the spectral information (FTIR) it was observed that the cross-linking between CS and TPP was taking place while the main structure of chitosan was the same. The dynamic light scattering results showed that water-soluble nanoparticles had a multimodal size distribution pattern, while low molecular particles yielded monodisperse particle distribution with an average size of ~45 nm, which was directly ascribed to the role of ultrasonication process. The morphology of nanoparticles was observed by SEM and TEM techniques. The mean diameter of nanoparticles was obtained in a range of 30 nm to 45 nm with a narrow size distribution and polydispersity index smaller than 0.2. Cytotoxicity of CS nanoparticles on human umbilical valve endothelial cells (HUVEC) was assessed by CCK-8 assay, as well as "Live/ Dead" assay and subsequent fl uorescent imaging. The results showed no to minimal cytotoxicity for CS solutions up to 50 μg/ml, while sporadic dead cells observed for 100 μg/ml solutions. This suggested that our monodisperse nanoparticle systems are great candidates to be used for drug delivery systems.

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“…La actividad antibacteriana de los PUs se evaluó con base en el método definido por Kara 31 contra E. coli (ATCC ® 2469), S. aureus (ATCC ® 6538) y P. aeruginosa (ATCC ® 27853). Las suspensiones bacterianas se obtuvieron por crecimiento en TSB a 37 °C por 16 h. Alícuotas de la suspensión bacteriana se inocularon en TSB nuevo a 37 °C por 6 h. Se centrifugó la suspensión bacteriana a 3000 rpm por 10 min.…”

Section: Ensayos Antibacterianos De Pusunclassified

Actividad antibacteriana, degradación hidrolítica y microbiana y citotoxicidad in vitro de poliuretanos sintetizados con polioles derivados del aceite de higuerilla

Uscátegui¹,

Díaz²,

Valero³

2016

Quim. Nova

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ANTIBACTERIAL ACTIVITY, HYDROLYTIC AND MICROBIAL DEGRADATION AND in vitro CYTOTOXICITY OF POLYURETHANE SYNTHESIZED WITH POLYOLS FROM CASTOR OIL DERIVATIVES. Biological activities from polyurethanes (PUs) synthesized from polyols (derived from castor oil) and isophorone diisocyanate were evaluated. In vitro degradability was evaluated by phosphate buffered saline (PBS) and antibacterial degradation with Escherichia coli and Pseudomonas aeruginosa. The biocompatibility was analyzed by: i) the antimicrobial activity against E. coli, S. aureus and P. aeruginosa, and ii) in vitro cytotoxicity assays using mouse embryonic fibroblast cell line L-929 in direct contact with the PUs and with NIH/3T3 cells in indirect contact with the PUs degradation products. PUs with polyol P1 (2,64% molar relation of pentaerythritol and castor oil) was the material with better biodegradation properties: 1.125±0.110% in 72 h by PBS at 100 °C. In general, all materials were degraded up to 1.000±0.223% and 2.251±0.010% in 72 h by E. coli and P. aeruginosa, respectively. On the other hand, it was determined a close relationship between functionality of polyol and bacterial inhibition. The antibacterial effect of the PUs decreased by 67% for E. coli, 55% for S. aureus and 56% for P. aeruginosa after 24 h. Chemical modification of castor oil did not generate a cytotoxic effect on the tested cell lines. The evaluated materials are suggested as candidates to obtain biomaterials due to their mechanical properties and biocompatibility presented in untransformed cells.Keywords: castor oil; polycaprolactone; cytotoxicity; degradability; biomedical applications. INTRODUCCIÓNLos poliuretanos (PUs) representan una popular e importante parte de productos industriales que se caracterizan por tener buenas propiedades de flexibilidad, elevada resistencia al impacto y durabilidad, características que lo convierten en polímeros con múltiples aplicaciones. 1 Su carácter de copolímero en bloque los dota de una amplia versatilidad en términos de adaptación de sus propiedades físicas y compatibilidad. 2-7 Es así como los PUs son interesantes para usos internos (in vivo), especialmente en aplicaciones a corto plazo, como catéteres o implantes. De igual forma, son interesantes para aplicaciones de uso externo (in vitro), como por ejemplo los sistemas de liberación controlada de medicamentos. 8 De esta forma los PUs son polímeros sintéticos biocompatibles que se emplean en dispositivos médicos y en aplicaciones de ingeniería de tejidos. Los PUs empleados como materiales biomédicos deben cumplir con las propiedades mecánicas para la aplicación destino, deben ser no tóxicos, ser biodegradables de acuerdo con la función a cumplir y deben ser biocompatibles. 9,10 Se han utilizado estrategias para mejorar falencias de estos materiales como las propiedades de fatiga, control de la degradación, incremento de proliferación celular, entre otros. Algunas de estas estrategias consisten en modificar la superficie de los PUs por medio de procesos físicos o químicos. 11 La eval...

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Synthesis and surface modification of polyurethanes with chitosan for antibacterial properties

Cited by 148 publications

References 54 publications

Photostabilizing Efficiency of Poly(vinyl chloride) in the Presence of Organotin(IV) Complexes as Photostabilizers

Photostabilizing Efficiency of Poly(vinyl chloride) in the Presence of Organotin(IV) Complexes as Photostabilizers

Highly Monodisperse Chitosan Nanoparticles Prepared by a Combined Triple-Method for Potential Use as Drug Carriers

Actividad antibacteriana, degradación hidrolítica y microbiana y citotoxicidad in vitro de poliuretanos sintetizados con polioles derivados del aceite de higuerilla

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