Synthesis and surface modification of magnetic nanoparticles for potential applications in sarcomas

Abstract

The application of nano-science in cancer therapy has become one of the most attractive tools in scientific research because of its versatility in diagnosis and treatment. Among the different types of nanoparticles, iron oxide nanoparticles (IONPs) are renowned for their low toxicity and suitability for therapeutic and diagnostic, or 'theragnostic,' approach against different types of cancers. Research investigating the effect of IONPs with different physiochemical characteristics in sarcoma is limited. In this study, we initially prepared IONPs of different sizes (200, 100, 20, and 10 nm) and modified their surface with different types of coatings (polyethylene glycol, D-glucose, and silica) under mild conditions. Various methods were used to illustrate and quantify cellular uptake of magnetic nanoparticles in sarcoma cell lines. Finally, the safety of the uptaken nanoparticles on diverse human sarcoma cell lines was investigated and found that the readily available IONPs can be taken up by synovial sarcoma and liposarcoma cell lines in the selective histological tumor types; however, they seem highly toxic for fibrous histiocytoma and fibrosarcoma.

Nanotechnology in Glycomics: Applications in Diagnostics, Therapy, Imaging, and Separation Processes

“…observed a significant level of cytotoxicity (approx. 80%) when the HT1080 sarcoma cell line was treated with iron oxide NPs (100 or 200 nm in diameter) coated with glucose, but a similar effect was observed with NPs coated by polyethylene glycol, suggesting the low targeting capability of such conjugates …”

Enhancement of TiO2 NPs Activity by Fe3O4 Nano-Seeds for Removal of Organic Pollutants in Water

“…Fe 3 O 4 NPs, presenting a superparamagnetic behavior below a typical critical dimension [14], have been evaluated as potential magnetic cores for Fe 3 O 4 @TiO 2 hybrid material in order to facilitate the recovery (and recycling) of the catalyst applying an external magnetic field [15,16,17,18,19,20,21]. Generally, a thick SiO 2 layer is inserted between the internal core (Fe 3 O 4 ) and the external catalyst (TiO 2 ) to prevent the Fe 3 O 4 -TiO 2 direct contact that would decrease the photodegradation activity [22,23,24,25].…”