Synthesis and testing of a triaza-cyclopenta[b]phenanthrene scaffold as a DNA binding agent

A hitchhiker's guide to G-quadruplex ligands

“…52 Subsequently, the crescent-shape particularity of quinacridine was found in several other ligands, such as indoloquinolines (such as PSI99A), 53 cryptolepine and analogues, 54 quindolines (such as SYUIQ-5) whose efficiency has been demonstrated on telomeric and c-myc promoter quadruplexes, 55 or triazacyclopentaphenantrene. 56 Some of the previous examples perfectly illustrate the difficulty in obtaining ligands with high quadruplex-selectivity. Following the way paved by Wheelhouse and co-workers with biarylpyrimidines, 57 Neidle and co-workers succeeded in combining good overlap of G-quartet and simple synthetic access, with ligands assembled via click-chemistry.…”

Retraction: Human telomeric G‐quadruplex: targeting with small molecules

“…The crescent‐shape particularity of quinacridine has also been found in several other ligands (Fig. 2), such as indoloquinolines [54–56], cryptolepine and its analogues [57], quindolines [58–61] and triazacyclopentaphenantrene [62].…”