Synthesis and Theoretical Study of New Quinazolinone Derivatives Containing Various Heterocyclic Moieties

Abdulgane, Hadel A; Kamel, Barakat A. F.; Askar, Firyal W.; Mohammed, Hammed H.

doi:10.7897/2230-8407.09576

Cited by 3 publications

(2 citation statements)

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“…Peaks 3 and 4 which were tentatively identified as quinoxaline derivatives using MS and MS/MS could not be identified in CC and HKC at 276 nm. The reason is probably low molar absorption coefficients for these heterocyclic compounds at this wavelength [30]. Peak 11 contains IS and peak 12 contains the suggested TDA fatty acid adduct (see Fig.10B).…”

Section: Resultsmentioning

confidence: 98%

Removal of toluene diamine and its derivatives from polyurethane foam using immobilized Trametes versicolor

2019

Adv. Environ. Biol

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Background: In addition to uses in home furnishings and the construction sector, polyurethane foam (PUF) is also prevalent in medical products such as scaffolds and implants. However, these applications raise concerns for human health as the use of this material can result in exposure to the carcinogenic substance 2,4-toluenediamine (2,4-TDA). The objective of this study was to identify easily extracted PUF-residuals and to study the removal of them in a biodegradation experiment including immobilized Trametes versicolor. Ultra-high-performance liquid chromatography-quadrupole/time of flight mass spectrometry (UHPLC-Q-TOF MS) was used in MS and MS/MS-mode to confirm the identities of PUF-related compounds and follow their concentration changes. Results: Except for 2,4-TDA and 2,6-TDA which were confirmed by standards, previously not reported substances were tentatively identified, among them TDA-dimers. These dimers include homodimers, heterodimers containing 2,4-TDA and 2,6-TDA and compounds that are hydroxylated. The experiments that were performed in an acidic fungal culture revealed a not previously described removal of these compounds below the approximate nM detection limit. The mechanisms behind their removal may include biosorption to fungal mycelia, bioaccumulation, use of them as nutrients or extracellular catabolism. Conclusion: The results of this study not only highlight the ease by which harmful compounds were extracted from the investigated PUF-quality which is used in non-medical applications, but also the possibility to use fungal-based methods to eliminate them. This could be facilitated by an initial extraction of PUF (excluding fungi) followed by a removal of the substances with PUF-immobilized Trametes versicolor. The findings in this study may be of interest to further investigate PUF-residuals in products aimed for medical applications.Citation: Åke Stenholm et al., 2019. Removal of toluene diamine and its derivatives from polyurethane foam using immobilized Trametes versicolor. Advances in Environmental Biology 13(2): 17-29.

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Section: Resultsmentioning

confidence: 98%

Removal of toluene diamine and its derivatives from polyurethane foam using immobilized Trametes versicolor

2019

Adv. Environ. Biol

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“…Metformin tablets also help reduce body weight or at least weight stability. Most tablets are used to treat high blood sugar that causes increased body weight [7]. Metformin hydrochloride is freely soluble in water and practically soluble in acetone, ether, and chloroform, and pH of a 1% water solution of metformin hydrochloride is 6.68 [8].…”

Section: Introductionmentioning

confidence: 99%

Preparation, Diagnosis, Biological Activity, and Theoretical Studies of Some Mixed Drug Complexes

Abbas

Kamel

Khamais

2019

The Scientific World Journal

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This paper includes synthesis and characterization of mixed ligand complexes derived from mefenamic acid and metformin using transition metal ions such as Co(II) and Cu(II). These complexes have been characterized by magnetic susceptibility, molar conductance, TG analyses, and spectral techniques such as FTIR and UV spectra. The theoretical study of the ligands and their complexes using semiempirical (PM6) method was used to measure IR and UV spectroscopy, HOMO-LUMO categories of the ligands. These synthesized complexes are also studied for their biological activities. The studies made on these complexes proposed a six octahedral geometry.

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Computational insights into the reaction mechanism of the synthesis of quinazoline derivatives via the cyclocondensation reaction between methyl 2-amino-4-(2-diethylaminoethoxy)-5-methoxybenzoate and formamide

Tenambo,

Adjieufack,

Ewonkem

et al. 2024

Computational and Theoretical Chemistry

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Synthesis and Theoretical Study of New Quinazolinone Derivatives Containing Various Heterocyclic Moieties

Abstract: In this work, quinazolinone derivatives were prepared, characterized by IR, UV, HNMR spectroscopy. Theoretically these compounds were studied

Cited by 3 publications

References 1 publication

Removal of toluene diamine and its derivatives from polyurethane foam using immobilized Trametes versicolor

Removal of toluene diamine and its derivatives from polyurethane foam using immobilized Trametes versicolor

Preparation, Diagnosis, Biological Activity, and Theoretical Studies of Some Mixed Drug Complexes

Computational insights into the reaction mechanism of the synthesis of quinazoline derivatives via the cyclocondensation reaction between methyl 2-amino-4-(2-diethylaminoethoxy)-5-methoxybenzoate and formamide

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