Synthesis and therapeutic potential of silver nanomaterials derived from plant extracts

Fahimirad, Shohreh; Ajalloueian, Fatemeh; Ghorbanpour, Mansour

doi:10.1016/j.ecoenv.2018.10.017

Cited by 139 publications

(75 citation statements)

References 130 publications

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“…The use of plant extracts for the synthesis of metal nanoparticles has attracted increasing interest in the last years due to its advantages over traditional chemical methods as well as over the utilization of bacteria, fungi or other living organisms. A review of the literature shows that the production of nanoparticles by this approach is easy, fast and cost-effective [23,24]. Recently, agro-industrial wastes have been investigated as potential starting materials for the green synthesis of nanoparticles [12][13][14]25].…”

Section: Discussionmentioning

confidence: 99%

Green Synthesis of Silver Nanoparticles Using Bilberry and Red Currant Waste Extracts

et al. 2019

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The production of silver nanoparticles (Ag-NPs) from bilberry waste (BW) and red currant waste (RCW) extracts was studied. Red fruit extracts were obtained by treating BW and RCW with aqueous ethanol (50% v/v) at 40 °C. The formation of nanoparticles was monitored spectrophotometrically by measuring the intensity of the surface plasmon resonance band (SPR) of silver. The effects of temperature (20–60 °C) and pH (8–12) on the reaction kinetics and on the properties of Ag-NPs were investigated. Characterization by XRD and dynamic light scattering (DLS) techniques showed that Ag-NPs were highly crystalline, with a face-centered cubic structure and a hydrodynamic diameter of 25–65 nm. The zeta potential was in the range of −35.6 to −20.5 mV. Nanoparticles obtained from BW were slightly smaller and more stable than those from RCW. A kinetic analysis by the initial-rate method showed that there was an optimum pH, around 11, for the production of Ag-NPs. Overall, the results obtained suggest that BW and RCW can be advantageously used as a source of reducing and stabilizing agents for the green synthesis of Ag-NPs.

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Section: Discussionmentioning

confidence: 99%

Green Synthesis of Silver Nanoparticles Using Bilberry and Red Currant Waste Extracts

et al. 2019

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“…Additionally, researchers started to report the application of silver nanoparticles in drug delivery for cancer treatment in the recent years. Some of the properties that make silver nanoparticles good candidates for potential applications in cancer are: relative lower toxicity and biological activities such as antimicrobial, inflammatory, and intrinsic therapeutic properties [42][43][44].…”

Section: Inorganic Nanoparticlesmentioning

confidence: 99%

Encapsulation for Cancer Therapy

et al. 2020

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The current rapid advancement of numerous nanotechnology tools is being employed in treatment of many terminal diseases such as cancer. Nanocapsules (NCs) containing an anti-cancer drug offer a very promising alternative to conventional treatments, mostly due to their targeted delivery and precise action, and thereby they can be used in distinct applications: as biosensors or in medical imaging, allowing for cancer detection as well as agents/carriers in targeted drug delivery. The possibility of using different systems—inorganic nanoparticles, dendrimers, proteins, polymeric micelles, liposomes, carbon nanotubes (CNTs), quantum dots (QDs), biopolymeric nanoparticles and their combinations—offers multiple benefits to early cancer detection as well as controlled drug delivery to specific locations. This review focused on the key and recent progress in the encapsulation of anticancer drugs that include methods of preparation, drug loading and drug release mechanism on the presented nanosystems. Furthermore, the future directions in applications of various nanoparticles are highlighted.

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“…Nanotechnology is a promising field with the potential for integration into various industrial and biotechnological sectors, such as pharmaceuticals, agriculture, cosmetics, biodegradation, and wastewater treatment [ 1 , 2 , 3 , 4 ]. Nanoparticles (NPs) are referred to as those particles with a size ranging between 1 and 100 nm and with distinctive physico-chemical properties [ 5 , 6 , 7 ].…”

Section: Introductionmentioning

confidence: 99%

Bactericidal and In-Vitro Cytotoxic Efficacy of Silver Nanoparticles (Ag-NPs) Fabricated by Endophytic Actinomycetes and Their Use as Coating for the Textile Fabrics

et al. 2020

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An endophytic strain of Streptomyces antimycoticus L-1 was isolated from healthy medicinal plant leaves of Mentha longifolia L. and used for the green synthesis of silver nanoparticles (Ag-NPs), through the use of secreted enzymes and proteins. UV–vis spectroscopy, Fourier-transform infrared (FT-IR), transmission electron microscopy (TEM), X-ray diffraction (XRD), and dynamic light scattering (DLS) analyses of the Ag-NPs were carried out. The XRD, TEM, and FT-IR analysis results demonstrated the successful biosynthesis of crystalline, spherical Ag-NPs with a particle size of 13–40 nm. Further, the stability of the Ag-NPs was assessed by detecting the surface Plasmon resonance (SPR) at 415 nm for one month or by measuring the NPs surface charge (−19.2 mV) by zeta potential analysis (ζ). The green-synthesized Ag-NPs exhibited broad-spectrum antibacterial activity at different concentrations (6.25–100 ppm) against the pathogens Staphylococcus aureus, Bacillus subtilis Pseudomonas aeruginosa, Escherichia coli, and Salmonella typhimurium with a clear inhibition zone ranging from (9.5 ± 0.4) nm to (21.7 ± 1.0) mm. Furthermore, the green-synthesized Ag-NPs displayed high efficacy against the Caco-2 cancerous cell line (the half maximal inhibitory concentration (IC50) = 5.7 ± 0.2 ppm). With respect to antibacterial and in-vitro cytotoxicity analyses, the Ag-NPs concentration of 100 ppm was selected as a safe dose for loading onto cotton fabrics. The scanning electron microscopy connected with energy-dispersive X-ray spectroscopy (SEM-EDX) for the nano-finished fabrics showed the distribution of Ag-NPs as 2% of the total fabric elements. Moreover, the nano-finished fabrics exhibited more activity against pathogenic Gram-positive and Gram-negative bacteria, even after 10 washing cycles, indicating the stability of the treated fabrics.

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Synthesis and therapeutic potential of silver nanomaterials derived from plant extracts

Cited by 139 publications

References 130 publications

Green Synthesis of Silver Nanoparticles Using Bilberry and Red Currant Waste Extracts

Green Synthesis of Silver Nanoparticles Using Bilberry and Red Currant Waste Extracts

Encapsulation for Cancer Therapy

Bactericidal and In-Vitro Cytotoxic Efficacy of Silver Nanoparticles (Ag-NPs) Fabricated by Endophytic Actinomycetes and Their Use as Coating for the Textile Fabrics

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