2024
DOI: 10.1002/cbic.202400391
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Synthesis and Thermodynamic Evaluation of Sialyl‐Tn MUC1 Glycopeptides Binding to Macrophage Galactose‐Type Lectin

Ramya Ayyalasomayajula,
Ivet Boneva,
David Ormaza
et al.

Abstract: Interactions between the tumor‐associated carbohydrate antigens of Mucin 1 (MUC1) and the carbohydrate‐binding proteins, lectins, often lead to the creation of a pro‐tumor microenvironment favoring tumor initiation, progression, metastasis, and immune evasion. Macrophage galactose binding lectin (MGL) is a C‐type lectin receptor found on antigen‐presenting cells that facilitates the uptake of carbohydrate antigens for antigen presentation, modulating the immune response homeostasis, autoimmunity, and cancer. C… Show more

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