Synthesis and transformations of vinylcaprolactam Part 1. Polymerization in presence of hydrogen peroxide

Shostakovsky, M. F.; Sidel'kovskaya, F. P.; Zelenskaya, M. G.

doi:10.1007/bf01164930

Cited by 4 publications

(1 citation statement)

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“…The monomer, NVCL, is an amphiphilic compound that is soluble in both polar and non-polar solvents. The first polymerization of NVCL was described by Shostakovski et al and published in the Russian language in 1952 [172]. The synthesis and the bulk polymerization PNVCL was later described in English by Solomon et al in 1968 [156].…”

Section: Poly-n-vinylcaprolactammentioning

confidence: 99%

Chitosan-Based Biocompatible Copolymers for Thermoresponsive Drug Delivery Systems: On the Development of a Standardization System

Marsili

Berti

et al. 2021

Pharmaceutics

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Chitosan is a natural polysaccharide that is considered to be biocompatible, biodegradable and non-toxic. The polymer has been used in drug delivery applications for its positive charge, which allows for adhesion with and recognition of biological tissues via non-covalent interactions. In recent times, chitosan has been used for the preparation of graft copolymers with thermoresponsive polymers such as poly-N-vinylcaprolactam (PNVCL) and poly-N-isopropylamide (PNIPAM), allowing the combination of the biodegradability of the natural polymer with the ability to respond to changes in temperature. Due to the growing interest in the utilization of thermoresponsive polymers in the biological context, it is necessary to increase the knowledge of the key principles of thermoresponsivity in order to obtain comparable results between different studies or applications. In the present review, we provide an overview of the basic principles of thermoresponsivity, as well as a description of the main polysaccharides and thermoresponsive materials, with a special focus on chitosan and poly-N-Vinyl caprolactam (PNVCL) and their biomedical applications.

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Section: Poly-n-vinylcaprolactammentioning

confidence: 99%

Chitosan-Based Biocompatible Copolymers for Thermoresponsive Drug Delivery Systems: On the Development of a Standardization System

Marsili

Berti

et al. 2021

Pharmaceutics

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Conventional Free Radical Polymerization of N‐Vinyl Caprolactam Homopolymers

Tallon

Musa

2021

Handbook of Pyrrolidone and Caprolactam Based Materials

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This chapter focuses on the various production routes to manufacture soluble and crosslinked versions of polyvinyl caprolactam (PVCL) by free‐radical polymerization, and how each route can affect the polymer's final properties. It discusses that the methodologies include solution polymerization, emulsion polymerization, and dispersion polymerization routes. N‐VCL is a seven‐membered cyclic amide that is a structural relative to N‐vinyl pyrrolidone. Homopolymerization of N‐VCL using t‐butyl peroxide was only initiated at 100 °C to achieve a decent polymerization level. Several studies have investigated the effect of chain‐transfer agents's on the polymerization kinetics of a N‐VCL polymerization. The chapter shows that many factors influence the free‐radical polymerization rate; from solvent, temperature, initiator‐type, monomer reactivity, additives, and polymerization‐type such as solution, emulsion, or precipitation. PVCL forms clear films with a semigloss appearance that exhibits both hydrophilic and hydrophobic properties. Synthetic approaches have included solution polymerization employing conventional free‐radical polymerization; bulk polymerization, emulsion, precipitation, or suspension polymerization.

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