Synthesis and tuberculostatic activity of aminoquinazoline derivatives

Design, synthesis, antimicrobial activity and anti-HIV activity evaluation of novel hybrid quinazoline–triazine derivatives

“…Several observations indicate that s-triazine analogues are the widely studied heterocyclic compounds owing to their broad spectrum of biological activity, including antimicrobial [7][8][9][10] , antimycobacterial 11 , anticancer 12,13 , antimalarial 14 and anti-HIV (NNRTIs) properties 15 . The biological importance of quinazoline had already stimulated the medicinal chemists to consider it as a building block due to its broad range of pharmacological properties, such as antimicrobial [16][17][18] , anti-HIV and anti-TMV (Tobacco Mosaic Virus) 19,20 , antitubercular 21 , anticancer 22 , anti-inflammatory 23 , anticonvulsant 24 , antidepressant 25 , hypolipidemic 26 , antiulcer 27 , analgesic 28 and immunotropic activities 29 . Moreover, piperazine heterocycles are valuable structural units in drug research [30][31][32][33][34][35][36] .…”

Synthesis, Spectroscopic Characterization and X-Ray Analysis of 6-Nitroquinazoline-2,4(1h,3h)-Dione

“…As medicines, many of them display antifungal 1 , antimicrobial 2 , anti-HIV 3 , antitubercular 4 , anticancer 5 , antiinflammatory 6 , anticonvulsant 7 , antidepressant 8 , hypolipidemic 9 , antiulcer 10 , analgesic 11 or immu-notropic activities 12 and are also known to act as thymidyalate synthase 13 , poly(ADP-ribose) polymerase (PARP) 14 , and protein tyrosine kinase 15 inhibitors. As pesticides, they are used as insecticides 16 and fungicides 17 .…”

Synthesis and Evaluation of Novel 4‐Substituted Styryl Quinazolines as Potential Antimicrobial Agents

“…One of the most repeatedly encountered heterocycles in medicinal chemistry is quinazoline because of its broad range of pharmacological activities. As medicines, many of its derivatives display antifungal 10, antimicrobial 11, anti‐HIV, and anti‐tobacco mosaic virus (TMV) 12, 13, antitubercular 14, anticancer 15, anti‐inflammatory 16, anticonvulsant 17, antidepressant 18, hypolipidemic 19, antiulcer 20, analgesic 21, or immunotropic activities 22. They are also known to act as thymidylate synthase 23, poly(ADP‐ribose) polymerase (PARP) 24, and protein tyrosine kinase inhibitors 25.…”