Synthesis and tuberculostatic activity of functionalized pyrazoles derived from (trifluoromethyl)pyrazole containing a hydrazone group

Crystal structure of ethyl 3-(trifluoromethyl)-1H-pyrazole-4-carboxylate, C7H7F3N2O2

“…Pyrazole derived compounds possess a wide range of biological activities including antimicrobial, antiviral, antiinflammatory, anticancer, analgesic, antipyretic [6][7][8]; accordingly, the pyrazole fragment represents an important component of a number of therapeutic drugs [8 and references therein]. The presence of fluoroalkyl substituents on the pyrazole ring, as is the case with the pyrazole based drug Celebrex, can improve the lipophilicity and solubility of a molecule and thus influence its biological activity [9]. Also, the incorporation of carboxylic acid groups and carboxylic ester functionality facilitates further modification and improvement of bioactivity of the pyrazole based molecules [10].…”