Synthesis and utilization of α-aminophosphine oxides and related derivatives

TEMPO/PhI(OAc)2 promotes the α-aminophosphinoylation of alcohols with amines and H-phosphine oxides in aqueous medium

“…8 Recently, great efforts has been made to overcome these limitations on reaction applicability and green sustainability. 9 For example, some protocols that are environmentally friendly, solvent-free, and catalyst-free have been successfully implemented for the three-component coupling of carbonyl, amine, and P(O)–H compounds. 9 b , c However, these reactions necessitate the utilization of aldehydes or ketones as essential reactants.…”