Synthesis and vasodilator activity of new 1,4-dihyropyridines bearing sulfonylurea, urea and thiourea moieties

New pyridine and chromene scaffolds as potent vasorelaxant and anticancer agents

“…For instance, compound 3a which is a representative member of the pyridine-3-carbonitrile series 3a-o, showed a strong stretching IR band at n ¼ Considering compound 4a as a representative example for the chromene-3-carbonitrile analogs 4a-e, strong stretching vibrational bands were evident at n ¼ 3449, 3348 cm À1 for (NH 2 ), and at n ¼ 2187 cm À1 for (C^N). Moreover, the 1 13 C NMR, MS) and exhibited similar features to those discussed for 3a and 4a (cf. Experimental section), the spectral charts (IR, 1 H-, 13 C-NMR and MS) of the new synthesized compounds are available in the ESI (Fig.…”

“…Moreover, the 1 13 C NMR, MS) and exhibited similar features to those discussed for 3a and 4a (cf. Experimental section), the spectral charts (IR, 1 H-, 13 C-NMR and MS) of the new synthesized compounds are available in the ESI (Fig. S1-S79 †).…”

“…However, despite the progress in the newly developed targeted therapies, these treatment strategies mainly depend on vasodilation to reduce blood pressure. 13 As a result, the drawbacks on systemic hypotension and limited efficiency are still challenging clinical problems, leading to poor prognosis. 14 Thus, new antihypertensive therapeutics acting on a range of therapeutic targets are urgently needed to control hypertension more effectively and minimize adverse side-effects that are oen associated with conventional agents.…”

“…IR spectra (KBr) were recorded on a JASCO 6100 spectrophotometer. NMR spectra were recorded on a JEOL AS 500 ( 1 H: 500 MHz, 13 C: 125 MHz) and a BRUKER 400 ( 1 H: 400, 13 C: 100 MHz) spectrometers. Mass spectra were recorded on a Shimadzu GCMS-QP 1000 EX (EI, 70 eV) spectrometer, Elemental microanalyses were recorded on a Vario El Elementar analyzer, ylidenemalononitrile 2a-m were prepared according to previously reported procedure.…”

“…7.26 (m, 2H), 7.40-7.49 (m, 3H) 13. C-NMR (100 MHz, CDCl 3 ): d 26.07, 27.63, 29.07, 32.07, 39.57, 54.13, 93.73, 115.57, 128.42, 128.62, 128.76, 129.23, 136.36, 154.97, 161.99, 166.60.…”