Synthesis and X-ray structures of new cycloalka[e]pyrano[2,3-b]pyridine derivatives: novel tacrine analogues

7-Methoxy-2-phenylquinoline-3-carbaldehyde

“…For related structures, see: Abdel-Wahab et al (2012); Benzerka et al (2011Benzerka et al ( , 2012Benzerka et al ( , 2013. For our previously work on the imidazol unit, see: Bouraiou et al (2011); Hayour et al (2011); Benzerka et al (2012).…”

2-p-Tolyl-2,3-dihydroquinolin-4(1H)-one

“…For applications of quinolines, see: Hepworth (1984). For the synthesis and applications of similar compounds see: Donnelly & Farrell (1990a,b); Chandrasekhar et al (2007); Kumar et al (2004); Gordon (2001); Olivier-Bourbigou & Magna (2002); Tokes & Szilagyi (1987); Tokes & Litkei (1993); Benzerka et al (2012Benzerka et al ( , 2013; Hayour et al (2011) Chelghoum et al (2012). For related structures, see: Tokes et al (1992); Benzerka et al Hydrogen-bond geometry (Å , ).…”

“…Some of them are of limited synthetic scope due to low yields, long reaction times, and the need for a large amount of catalyst, specialized solvents (Tokes & Szilagyi, 1987;Tokes et al, 1992), or microwave activation (Kumar et al, 2004;Gordon, 2001;Olivier-Bourbigou & Magna, 2002). As part of our continuingeffort toward the development of new methods for the synthesis of biologically relevant heterocyclic compounds (Benzerka et al, 2012(Benzerka et al, , 2013Hayour et al, 2011), we have, recently, developed a procedure using butylmethylimidazolium(bmim).BF4 as a green solvent to provide an efficient and convenient protocol for the synthesis of 2,3-dihydroquinolin-4(1H)-ones from 2′-aminochalcones without the requirement for an additional catalyst (Chelghoum et al, 2012). We wish to describe herein the synthesis and singlecrystal X-ray structure of 2-p-tolyl-2,3-dihydroquinolin-4(1H)-one (I).…”

3-(1H-1,3-Benzimidazol-2-yl)-2,7-dimethoxyquinoline

“…For our previous work on the preparation of functionalized heterocyclic compounds with potential biological activity, see: Benzerka et al (2012); Hayour et al (2011). For further synthetic details, see: Fioraventi et al (2006).…”

“…In the course of our program related to the synthesis of new suitably functionalized heterocyclic compounds of potential biological activity, (Benzerka et al, 2012;Hayour et al, 2011), we now report herein the synthesis and structure determination of the title compound, C 18 H 15 N 3 O 2 . The reactivity of this compound and its analogues toward nucleophiles is under investigation.…”