Synthesis, Anti-breast Cancer Activity, and Molecular Docking Studies of Thiourea Benzamide Derivatives and Their Complexes with Copper Ion

Abstract

IntroductionThioureas are a well-known class of versatile organic compounds that have been extensively synthesized and investigated for many years due to their ability to undergo structural modification. 1 These compounds have proven to be industrially important by having two reactive primary amine group units. Thiourea can therefore be used to create a wide range of useful biologically interesting chemical groups, leading to an essentially infinite number of structures with novel physicochemical features. These properties add to the understanding of thiourea chemicals. [2][3][4] Compounds containing carbonyl and thiocarbonyl groups occupy a necessary position among organic reagents as workable donor ligands for transition metal ions. 5-6 Among these thiourea derivatives are potentially very versatile ligands and can coordinate to a range of metal centers as neutral ligands, monoanions, or dianions. [6][7] A wide range of thiourea applications in industries, chemistry, medicine, and other fields may be facilitated by the oxygen, nitrogen, and sulphur donor atoms of thiourea and its derivatives.