Synthesis, anti-inflammatory and analgesic activities evaluation of some mono, bi and tricyclic pyrimidine derivatives

Sondhi, Sham M.; Singh, Nishan; Johar, Monika; Kumar, Ashok

doi:10.1016/j.bmc.2005.06.063

Cited by 132 publications

(80 citation statements)

References 17 publications

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“…41,42 HeLa and C6 cells were used for the anticancer tests. The experiments were carried out at eight concentrations (5,10,20,30,40,50,75, and 100 µ M).…”

Section: Cell Culture and Cell Proliferation Assaymentioning

confidence: 99%

Synthesis and in vitro anticancer evaluation of 1,4-phenylene-bis-pyrimidine-2-amine derivatives

Gürdere¹,

Kamo²,

Yağlıoğlu³

et al. 2017

Turk J Chem

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A series of 1,4-phenylene-bis-chalcones 3a-3h were synthesized by the reaction of terephthalaldehyde with substituted arylketones in this study. The novel 1,4-phenylene-bis-pyrimidine-2-amine derivatives 5a-5h were obtained by the addition of guanidine hydrochloride to 1,4-phenylene-bis-chalcone 3a-3h in ethanolic KOH under reflux conditions.The structure of the compounds was explained by means of IR, 1 H NMR, 13 C NMR, and elemental analyses. The anticancer activities of 3a-3h and 5a-5h were investigated against rat brain tumor cells and human uterus carcinoma in vitro . Activity tests were performed as dose-dependent assays at eight concentrations. The positive control was 5fluorouracil (5-FU). Compounds 3c and 3d were examined and they showed high activities as compared to 5-FU against C6 (rat brain tumor) and HeLa (human uterus carcinoma) cells. The anticancer activity of 5h was better than that of 5-FU at high concentrations cell-selectively against C6 cells.

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“…41,42 HeLa and C6 cells were used for the anticancer tests. The experiments were carried out at eight concentrations (5,10,20,30,40,50,75, and 100 µ M).…”

Section: Cell Culture and Cell Proliferation Assaymentioning

confidence: 99%

Synthesis and in vitro anticancer evaluation of 1,4-phenylene-bis-pyrimidine-2-amine derivatives

Gürdere¹,

Kamo²,

Yağlıoğlu³

et al. 2017

Turk J Chem

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“…Pirisino et al 47 have studied 2-phenyl pyrazolo-4-ethyl-4, 7-dihydro [1, 5-a] pyrimidine-7-one for it's analgesic, antipyretic and anti-inflammatory activities the anti-inflammatory properties of synthesized compound were evaluated by carrageen an induced paw edema and cotton pellets induced granuloma method and found to posses the activity similar to indomethacin, phenylbutazone and isoxicam similarly this compound was shown to passes analgesic and antipyretic activity comparable to the former drugs. Sondhi et al 48 synthesized some mono, bi and tricyclic pyrimidine derivatives and evaluated them for analgesic activity using phenyl quinine writhing assay.…”

Section: Mass Spectra Of Pyrimidinesmentioning

confidence: 99%

Untitled

2010

IJPSR

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The chemistry of pyrimidine is a blossoming field. Numerous method for the synthesis of pyrimidine and also their diverse reactions offer enormous scope in the filed of medicinal chemistry. The utility of pyrimidines as synthon for various biologically active compounds has given impetus to these studies. The review article aims to review the work reported and the chemistry and biological activities of pyrimidines during past year.

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“…In addition, thiazoles play a prominent role in nature. For example, the thiazolium ring is present in vitamin B [11,12]. Also, large number of thiazole derivatives has emerged as active pharmaceutical ingredients in several drugs for their potential anti-inflammatory [13] and antitumor activities [14].…”

Section: Introductionmentioning

confidence: 99%

The Utility of 1-Cyanoacetyl-4-(4-Ethoxyphenyl) Thio-Semicarbazide for Synthesis of Pyrazole, Triazole, Thiazole, Pyridine and Chromene Derivatives

Thabet

Helal

Salem

et al. 2011

Al-Azhar Bulletin of Science

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Synthesis, anti-inflammatory and analgesic activities evaluation of some mono, bi and tricyclic pyrimidine derivatives

Cited by 132 publications

References 17 publications

Synthesis and in vitro anticancer evaluation of 1,4-phenylene-bis-pyrimidine-2-amine derivatives

Synthesis and in vitro anticancer evaluation of 1,4-phenylene-bis-pyrimidine-2-amine derivatives

Untitled

The Utility of 1-Cyanoacetyl-4-(4-Ethoxyphenyl) Thio-Semicarbazide for Synthesis of Pyrazole, Triazole, Thiazole, Pyridine and Chromene Derivatives

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