Synthesis, Antibacterial and Anthelmintic Activity of Novel 3-(3-Pyridyl)-oxazolidinone-5-methyl Ester Derivatives

Jin, Bo; Chen, Jiayi; Sheng, Zunlai; Sun, Meng-Qing; Yang, Hongliang

doi:10.3390/molecules27031103

Cited by 12 publications

(4 citation statements)

References 39 publications

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“…This compound, an LZD analogue, induced paralysis in worms in 3.6 min and subsequent death after 8.1 min. 177 It is worth noting that none of the compounds presented significant activity against Gram-positive bacteria, highlighting their high selectivity against parasites. Finally, oxazolidinone 110 ( Fig.…”

Section: Miscellaneous Oxazolidinonesmentioning

confidence: 99%

Oxazolidinones as versatile scaffolds in medicinal chemistry

et al. 2023

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Section: Miscellaneous Oxazolidinonesmentioning

confidence: 99%

Oxazolidinones as versatile scaffolds in medicinal chemistry

et al. 2023

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“…Paralysis was identified when the worms failed to recover even in normal saline. Death was determined when the worms lost their motility and their body colour faded away [25,26].…”

Section: -Bromo-n-(nn-dimethyl Carbamimidoyl)-4-oxo-2phenyl Quinazoli...mentioning

confidence: 99%

Synthesis, in silico Profiling, in vitro Anthelmintic and Antibacterial Activities of Novel 6-Bromo-2-Phenyl-3-Substituted Quinazolin-4(3H)-ones

Posinasetty,

Bandarapalle,

Pillarikuppam

et al. 2023

ajc

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In this study, eight novel derivatives of 6-bromo-2-phenyl-3-substituted quinazolin-4(3H)-ones were synthesized, which was achieved through the use of bromoanthranilic acid, benzoyl chloride, and different substituted amino synthons. The chemical structures of these compounds through IR spectroscopy, 1H NMR spectroscopy, and mass spectrometry were successfully characterized. By employing computational tools like PASS, Molinspiration, Osiris, and Swiss ADME, we made predictions about the properties of these molecules. These predictions encompassed factors such as anthelmintic and antibacterial traits, drug-likeness, bioactivity scores, toxicity, and potential molecular targets. Furthermore, we performed in vitro assays to evaluate the bioactivities of the synthesized compounds. For anthelmintic effectiveness, the conventional method of assessing paralysis and mortality in earthworms for each compound was followed. The antibacterial efficacy was tested against both Gram-positive and Gram-negative bacterial strains, using the agar cup plate technique. The results of these assays provide valuable insights into the potential of these compounds as agents with anthelmintic and antibacterial properties.

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“…Pyridine derivatives are widely used in medicine and agriculture because of their unique nitrogen-containing heterocyclic structure. , These derivatives often exhibit metal ion coordination ability, and some pyridine derivatives exhibit antifungal, insecticidal, and other biological activities. , …”

Section: Introductionmentioning

confidence: 99%

Synthesis and Characterization of Slow-Release Chitosan Oligosaccharide Pyridine Schiff Base Copper Complexes with Antifungal Activity

Liu,

Qin,

Liu

et al. 2024

J. Agric. Food Chem.

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Herein, a series of chitosan oligosaccharide copper complexes modified with pyridine groups (CPSx-Cu complexes) were successfully prepared via the Schiff base reaction and ion complexation reaction for slow-release fungicide. The structures of the synthesized derivatives were characterized via Fourier transform infrared spectroscopy and 1 H and 13 C nuclear magnetic resonance spectroscopy, and the unit configuration of the complexes was calculated using Gaussian software. The slow-release performance experiment demonstrated that the cumulative copper ion release rate of CPSx-Cu complexes was dependent on the type of substituents on the pyridine ring. Furthermore, the in vitro and in vivo antifungal activities of the CPSx-Cu complexes were investigated. At a concentration of 0.4 mg/mL, CPSx-Cu complexes completely inhibited the growth of Pythium vexans and Phytophthora capsici. Results indicated that CPSx-Cu complexes with slow-release ability exhibited better antifungal activity than thiodiazole-copper and copper sulfate basic. This study confirmed that combining chitosan oligosaccharide with bioactive pyridine groups and copper ions is an effective approach to further developing slow-release copper fungicides, providing new possibilities for the application of copper fungicides in green agriculture. This study lays the foundation for further studies on biogreen copper fungicides.

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Synthesis, Antibacterial and Anthelmintic Activity of Novel 3-(3-Pyridyl)-oxazolidinone-5-methyl Ester Derivatives

Cited by 12 publications

References 39 publications

Oxazolidinones as versatile scaffolds in medicinal chemistry

Oxazolidinones as versatile scaffolds in medicinal chemistry

Synthesis, in silico Profiling, in vitro Anthelmintic and Antibacterial Activities of Novel 6-Bromo-2-Phenyl-3-Substituted Quinazolin-4(3H)-ones

Synthesis and Characterization of Slow-Release Chitosan Oligosaccharide Pyridine Schiff Base Copper Complexes with Antifungal Activity

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