Synthesis, Antibacterial and Antifungal Activity of Some Novel 3,5‐Disubstituted‐1<i>H</i>‐1,2,4‐triazoles

Sharma, Shweta; Gangal, S. V.; Rauf, Abdur; Zahin, Maryam

doi:10.1002/ardp.200800005

Cited by 29 publications

(11 citation statements)

References 31 publications

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“…1,2,4-Triazole derivatives have consistently attracted scientific and practical interest because of their various chemical properties, synthetic versatility,a nd biologicala ctivities [2][3][4]. Difenoconazoleisanimportant representative of atriazole derivative, which has been used as the most efficient triazole fungicide [5,6].…”

Section: Discussionmentioning

confidence: 99%

Crystal structure of trans-3-chloro-4-[4-methyl-2-(1H-1,2,4-triazol-1- ylmethyl)-1,3-dioxolan-2-yl]phenyl-4-chlorophenyl ether, C19H17Cl2N3O3

Quangliang¹,

Chen²,

Yubin³

et al. 2014

Zeitschrift Für Kristallographie - New Crystal Structures

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C 19 H 17 Cl 2 N 3 O 3 ,monoclinic, C2/c (no. 15), a =25.792(7) Å, b =10.020(3) Å, c =15.054(4) Å, b =93.337(5)°, Source of materialThetitle compound is easily available by aliterature known synthesis [1]. It was recrystallized from am ethyl tert. butyle ther solution at room temperature to give colourless crystals suitable for single-crystal X-ray diffraction. Experimental detailsHa toms were positioned geometrically with C-H =0 .93, 0.97 and 0.96 Åfor aromatic, methylene and methyl, respectively, and constrained to ride on their parent atoms, with U iso (H) =1.2 (1.5 for methyl)times U eq (C). Difenoconazoleisanimportant representative of atriazole derivative, which has been used as the most efficient triazole fungicide [5,6]. But alot of waste residues are formed in the process of production. In order to get deeper insight into the reaction mechanism and to optimize the production process, the title compound wass eparated andi ts structure was characterized. As shown in thefigure,fourrings exist in the molecular structure. Two benzene rings and triazol ring are planar, while the dioxolan ring is bent. The dihedral angle between two benzene rings is 80.6°ow-ing to rotating and bending of the ether bond. The dioxolan ring adopts an envelope conformation, with the C17 atom deviating from the C18/O2/C13/O3 plane by 0.248(2) Å.Z. Kristallogr.

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Section: Discussionmentioning

confidence: 99%

Crystal structure of trans-3-chloro-4-[4-methyl-2-(1H-1,2,4-triazol-1- ylmethyl)-1,3-dioxolan-2-yl]phenyl-4-chlorophenyl ether, C19H17Cl2N3O3

Quangliang¹,

Chen²,

Yubin³

et al. 2014

Zeitschrift Für Kristallographie - New Crystal Structures

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“…1,2,4‐Triazole derivatives are very interested especially those compounds carrying imine bond due to their widely varying chemical properties, synthetic versatilities, and their acting as antibacterial antifungal antitubercular analgesic anti‐inflammatory anticancer anticonvulsant antiviral insecticidal antidepressant antiviral compounds, antihypertensive, and antitumerl agents …”

Section: Introductionmentioning

confidence: 99%

Green Synthesis of new Trizole Based Heterocyclic Amino Acids Ligands and their Transition Metal Complexes. Characterization, Kinetics, Antimicrobial and Docking Studies

El‐Saghier

El‐Halim

Abdel‐Rahman

et al. 2018

Applied Organom Chemis

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Two novel amino acids imine ligands (H 2 L 1 and H 2 L 2 ) have been synthesized using green condensation reaction from 2-[3-Amino-5-(2-hydroxy-phenyl)-5methyl-1,5-dihydro-[1, 2, 4]triazol-4-yl]-3-(1H-indol-3-yl)-propionic acid with benzaldehyde/p-flouro benzaldehyde (1:1 molar ratio) in the presence of lemon juice as a natural acidic catalyst in aqueous medium. Their transition metal complexes have been prepared in a molar ratio (1:1). Characterization of the ligands and complexes using elemental analysis, spectroscopic studies, 1 HNMR, 13 CNMR, and thermal analysis has been reported. E*, ΔH*, ΔS* and ΔG* thermodynamic parameters, were calculated to throw more light on the nature of changes accompanying the thermal decomposition process of these complexes. The molar conductance measurement of metal complexes showed nonelectrolyte behavior. The metal complexes of the two ligands have tetrahedral geometry with a general molecular structure [M(H 2 L)X n ], where [(M = Mn (II), Co (II), Cu (II) and Zn (II), X = Cl, n = 2]; M = VO (II), X = SO 4 , n = 1] for H 2 L 1 . [M = Co (II), Cu (II), Zn (II)] for H 2 L 2 . Antibacterial activity of the complexes against (Bacillis subtilis, Micrococcus luteus, Escherichia coli), also antifungal activity against (Aspergillus niger, Candida Glabarta, Saccharomyces cerevisiae) have been screened. The results showed that all complexes have antimicrobial activity higher than free ligands.Molecular docking studies results showed that, all the synthesized compounds having minimum binding energy and have good affinity toward the active pocket, thus, they may be considered as good inhibitor of targeting PDB code: 1SC7 (Human DNA Topo-isomerase I).

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“…1,2,4-Triazoles and their heterocyclic derivatives represent an interesting class of compounds possessing a wide spectrum of biological activities. A large number of 1,2,4-triazole containing ring systems exhibits antibacterial (Demirbas et al, 2005;Holla et al, 2000;Sharma et al, 2008;Turan-Zitouni et al, 2005), antifungal (Jalilian et al, 2000), antitubercular (Foroumadi et al, 2003), analgesic (Turan-Zitouni et al, 2001;Tozkoparan et al, 2007), insecticide (Chai et al, 2003), antidepressant (Varvaresou et al, 1998), central nervous system (CNS) (Modzelewska-Banachiewicz et al, 2004) activities.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, characterisation and antimicrobial activities of novel 7,9-diphenyl-1,2,4-triaza-8-oxa-spiro[4.5]-decan-3-thiones

Kabilan

Umamatheswari

2010

Med Chem Res

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Some new 7,9-diaryl-1,2,4-triaza-8-oxa-spiro [4.5]-decan-3-thiones has been synthesised and their antibacterial activity against Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa and Salmonella typhi, and antifungal activity against Candida albicans, Rhizopus sp., Aspergillus flavus and Aspergillus niger were examined. Compounds 14 and 15 against E. coli and S. typhi showed marked antibacterial activity. Similarly, compounds 13 and 15 against Rhizopus sp. and 13 and 14 against A. flavus exerted significant antifungal activities.

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Synthesis, Antibacterial and Antifungal Activity of Some Novel 3,5‐Disubstituted‐1H‐1,2,4‐triazoles

Cited by 29 publications

References 31 publications

Crystal structure of trans-3-chloro-4-[4-methyl-2-(1H-1,2,4-triazol-1- ylmethyl)-1,3-dioxolan-2-yl]phenyl-4-chlorophenyl ether, C19H17Cl2N3O3

Crystal structure of trans-3-chloro-4-[4-methyl-2-(1H-1,2,4-triazol-1- ylmethyl)-1,3-dioxolan-2-yl]phenyl-4-chlorophenyl ether, C19H17Cl2N3O3

Green Synthesis of new Trizole Based Heterocyclic Amino Acids Ligands and their Transition Metal Complexes. Characterization, Kinetics, Antimicrobial and Docking Studies

Synthesis, characterisation and antimicrobial activities of novel 7,9-diphenyl-1,2,4-triaza-8-oxa-spiro[4.5]-decan-3-thiones

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