Synthesis, Antibacterial and Antioxidant Properties of Pyrazolylpyridazines

Background & Introduction : Antioxidants are known to prevent oxidative stress-induced damage to the biomolecules and thus, delay the onset of cancers and many age-related diseases. Therefore, the development of novel and potent antioxidants is justified. Method: During this study, we synthesized symmetrical bis-Schiff bases of carbohydrazide 1-27, and evaluated their in vitro antioxidative activity and cytotoxic activity. Results: Among synthesized compounds, six compounds 20 (IC50 = 12.89 ± 0.02 µM), 16 (IC50 = 14.32 ± 0.43 µM), 17 (IC50 = 18.52 ± 0.83 µM), 19 (IC50 = 22.84 ± 0.62 µM), 24 (IC50 = 35.1 ± 0.82 µM) and 15 (IC50 = 40.03 ± 1.06 µM) showed an excellent 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity, better than the standard butylatedhydroxyanisole (BHA) (IC50 = 44.6 ± 0.6 µM). Likewise, two compounds 16 (IC50 = 4.3 ± 1.3 µM) and 20 (IC50 = 6.6 ± 1.6 µM) showed oxidative burst scavenging activity better than the standard drug ibuprofen (IC50 = 11.2 ± 1.9 µM). Some synthesized compounds showed good to moderate toxicity against prostate cancer (PC-3) cell lines. Conclusion: This study has identified potent antioxidants and good cytotoxic agents with the potential to further investigate.

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Synthesis of Novel Compounds with a Combination of Pyridazine, Pyrazole and 1,3,5-Triazine Rings and Preliminary Evaluation of Their Plant Growth Stimulant Activity

Shainova

Gomktsyan

Karapetyan

et al. 2017

Journal of Chemical Research

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The syntheses of a series of novel compounds with a combination of pyrazole and pyridazine rings and their corresponding pyrazolyl-1-N-substituted derivatives were carried out. These rings are connected through the oxygen atom and oxoethoxy or oxoethyl moieties. At preliminary screening the synthesised compounds have shown pronounced plant growth stimulant activity. The most active compounds are being preparing for deeper studies and further field trials.

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Synthesis, Antibacterial and Antioxidant Properties of Pyrazolylpyridazines

Cited by 4 publications

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Synthesis and biological properties of novel 3-(pyrazol-1-yl)-6-oxopyridazine derivatives

Synthesis and biological properties of novel 3-(pyrazol-1-yl)-6-oxopyridazine derivatives

Synthesis and Evaluation of Bis-Schiff Bases of Carbohydrazide as Antioxidant and Cytotoxic Agents

Synthesis of Novel Compounds with a Combination of Pyridazine, Pyrazole and 1,3,5-Triazine Rings and Preliminary Evaluation of Their Plant Growth Stimulant Activity

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