2022
DOI: 10.1016/j.molstruc.2021.132135
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Synthesis, antibacterial and cytotoxic evaluation of cytosporone E and analogs

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Cited by 7 publications
(6 citation statements)
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“…Buiding on our previous work, we have demonstrated that certain 3-arylphthalides possess anti-MRSA properties similar to cytosporone E. [8] This is especially evident in compounds containing an OH group in position 5 and a CF 3 group on the aromatic ring, such as compounds 10 a and 10 b, both of which exhibit MIC values similar to those of cytosporone E (Table 2, entries 1-3). Therefore, we selected phthalide that one or more lipophilic groups on position 3 from the previously synthesized ones to compare their activity against MRSA with that of compounds 10 a-b.…”
Section: Antibacterial Assaysmentioning
confidence: 69%
See 1 more Smart Citation
“…Buiding on our previous work, we have demonstrated that certain 3-arylphthalides possess anti-MRSA properties similar to cytosporone E. [8] This is especially evident in compounds containing an OH group in position 5 and a CF 3 group on the aromatic ring, such as compounds 10 a and 10 b, both of which exhibit MIC values similar to those of cytosporone E (Table 2, entries 1-3). Therefore, we selected phthalide that one or more lipophilic groups on position 3 from the previously synthesized ones to compare their activity against MRSA with that of compounds 10 a-b.…”
Section: Antibacterial Assaysmentioning
confidence: 69%
“…[7] This work presents the optimisation and generalisation of the Friedel-Crafts approach for synthesising 3-arylphthalides from aromatic esters and aldehydes in a single step. Our group's previous work identified some of these 3-arylphthalides as relevant analogues of cytosporone E, [8] an antibacterial phthalide. [9] Consequently, we evaluated the antibiotic activities of selected analogues against a methicillin-resistant strain of Staphylococcus aureus.…”
Section: Introductionmentioning
confidence: 99%
“…Isobenzofuran, isobenzofuran-1(3H)-one and 3-hydroxyisobenzofuran-1(3H)-one heterocycle rings are structural motifs building up important pharmaceuticals and naturally occurring substances evidenced to have plausible radical scavenging potential [11]. These have been shown to possess bunch of therapeutic properties, such as anti-tumour [12,13], anti-diabetic [14,15], antimycotic [16], antibacterial [17][18][19][20], cytotoxic [17,19,21] and antioxidative [15,16,18,20,[22][23][24][25][26]. Fungi provide virtually endless natural source of that class of compounds [16,[27][28][29][30], with many of them already being successfully used, as for example griseofulvin.…”
Section: Introductionmentioning
confidence: 99%
“…Isobenzofuran, isobenzofuran-1(3H)-one and 3-hydroxyisobenzofuran-1(3H)-one heterocycle rings are structural motifs building up important pharmaceutical's and naturally occurring substances with plausible radical scavenging potential. [11] These have been shown to possess bunch of other therapeutic properties, such as anti-tumor [12,13], anti-diabetic [14,15], antimycotic [16], antibacterial [17][18][19][20],…”
Section: Introductionmentioning
confidence: 99%
“…cytotoxic [17,19,21] and antioxidative [15,16,18,20,[22][23][24][25][26]. Fungi provide a virtually endless natural supply of that class of compounds[16, [27][28][29][30], with many of them already being successfully used, as for example griseofulvin.…”
Section: Introductionmentioning
confidence: 99%