Synthesis, antibacterial, antielastase, antiurease and antioxidant activities of new methoxy substitued bis-1,2,4-triazole derivatives

Efficient synthesis of Some Novel Symmetrical and Unsymmetrical Pyridine bis-1,2,4-triazoles and bis-1,3,4-thiadiazoles

“…17 Moreover, it has been indicated in several reports that bisheterocyclic compounds displayed much better antibacterial activity than mono-heterocyclic compounds. [18][19][20][21] In view of these observations, and also in continuation of our previous work on the synthesis of bis-heterocyclic compounds, [22][23][24][25] we now report the synthesis of some novel pyridine bis-1,2,4-triazoles and bis-1,3,4-thiadiazoles.…”

Synthesis and Biological Evaluation of S-Substituted Perhalo-2-nitrobuta-1,3-dienes as Novel Xanthine Oxidase, Tyrosinase, Elastase, and Neuraminidase Inhibitors

“…In addition, Rodis and Digenis [68] reported that low molecular weight thiocarbamate compounds also have inhibitory effect on leukocyte elastase activity. Sokmen et al showed that triazole compounds which include halogen, carboxylate, heterocyclic sulfide, sulfone, and/or methoxy groups in their structure inhibit elastase enzyme [42]. In our study, it can be assumed that compounds which have halogen and sulfoxide groups in their structure inhibit elastase enzyme, yet, not in high ratio.…”

“…Elastase (EC: 3.4.21.37) is a serine protease of the chymotrypsin family that hydrolytically degrades extracellular matrix components such as elastin, fibronectin, collagen, proteoglycans, laminin, and some matrix metalloproteinases [42]. This enzyme is particularly abundant in the skin, arteries, lungs, and ligaments.…”

“…Neutrophil elastase plays an important role in some processes like blood coagulation, apoptosis, and inflammation. Inhibition of the elastase activity could be used for protection against various diseases such as chronic obstructive pulmonary disease, cystic fibrosis, acute respiratory distress syndrome, acute lung injury, ischemia, and reperfusion injury [42]. Neutrophil elastase also plays a main role in both acute pathogenesis and chronic functional recovery after traumatic brain injury [43].…”

Synthesis, antielastase, antioxidant and radical scavenging activities of 4-(aza substituted) methylene substituted dihydroxy coumarines

“…The inhibition was increased with increasing dihydroxy coumarin concentration ( 44 . Previous studies have shown that the attachment of various leaving groups (halogen, carboxylate, heterocyclic sulfide, sulfone, methoxy) to the triazole compound yields highly potent inhibitors of human leukocyte elastase 45 . We have demonstrated the potency of the dihydroxy coumarin derivatives to inhibit elastase.…”