Synthesis, antibacterial, antifungal and anti-HIV activities of Schiff and Mannich bases derived from isatin derivatives and N-[4-(4′-chlorophenyl)thiazol-2-yl] thiosemicarbazide

Pandeya, S. N.; Sriram, Dharmarajan; Nath, Gopal; Declercq, E.

doi:10.1016/s0928-0987(99)00038-x

Cited by 540 publications

(272 citation statements)

References 6 publications

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“…Recently, isatin derivatives have attracted strong interest in organic and medicinal chemistry due to their potent biological and pharmacological activities including antitumor (Premanathan et al, 2012;Havrylyuk et al, 2011), antimicrobial (Singh et al, 2010;Ali & Alam, 1994;Pandeya et al, 1999b), anti-inflammatory and analgesic (Abele et al, 2003;Mondal, et al, 2010), antimycobacterial (Aboul-Fadl et al, 2010;Sriram et al, 2006), anticonvulsant (Malawska, 2005), antiviral (Selvam et al, 2006;Selvam et al, 2008;Abbas et al, 2013), anthelmintic (Suresh et al, 2011), anti-HIV applications (Pandeya et al, 1999a) and anti-oxidant (Andreani et al, 2010;Kiran et al 2013). In this context, the present study reports the synthesis and crystal structure determination of the title bis-indole derivative.…”

Section: Structure Descriptionmentioning

confidence: 99%

3-Hydroxy-3-(2-oxo-2,3-dihydro-1H-indol-3-yl)-2,3-dihydro-1H-indol-2-one

et al. 2017

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The conformation of the title molecule, C16H12N2O3, is partly determined by an intramolecular C=O...π interaction between one carbonyl group and the five-membered ring of the other indolinone moiety. The crystal packing consists of layers parallel to (001) formed by a combination of N—H...O and O—H...O hydrogen bonds and π–π stacking interactions. Both the N—H...O and O—H...O hydrogen bonds generate inversion dimers.

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Section: Structure Descriptionmentioning

confidence: 99%

3-Hydroxy-3-(2-oxo-2,3-dihydro-1H-indol-3-yl)-2,3-dihydro-1H-indol-2-one

et al. 2017

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“…27 Good antibacterial and antifungal activities of Schiff and Mannich bases derived from isatin and thiolyl-thiosemicarbazide have also been described. 28 Some examples of these compounds are shown in Figure 2.…”

Section: Oxindoles and Their Biological Activitiesmentioning

confidence: 99%

Oxindoles and copper complexes with oxindole-derivatives as potential pharmacological agents

Cerchiaro

Ferreira

2006

J. Braz. Chem. Soc.

164

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Oxindóis são compostos endógenos encontrados em fluidos e tecidos de mamíferos. Particularmente, isatina (1H-indol-2,3-diona) e seus derivados vêm mostrando uma grande variedade de efeitos no meio biológico, incluindo a inibição de monoamina oxidase, atividade bactericida, fungicida, antiviral e antiproliferativa. Pesquisas mais recentes descrevem estes compostos como inibidores de quinases, uma classe de proteínas envolvidas em várias etapas do ciclo celular. Nesta revisão, complexos de cobre(II) com ligantes derivados de oxindóis são discutidos como potenciais agentes antitumorais, em comparação com outros complexos, com base na proposição de se aliar as propriedades redox e coordenativas do metal à capacidade de afetar os processos de angiogenese e apoptose já demonstrada por esse tipo de ligante.Oxindoles are endogenous compounds found in mammalian body fluids and tissues. Particularly, isatin (1H-indole-2,3-dione) and its derivatives have shown a variety of biological effects, including inhibition of monoamine oxidase, antibacterial, antifungal, antiviral and antiproliferative activities. Recent reports have described these compounds as efficient inhibitors of kinases, a class of proteins involved in many steps of the cellular cycle. Here, some copper(II) complexes with oxindole-derived ligands are discussed as potential antitumoral agents, in comparison to other complexes, based on the proposal of a synergistic effect on adding the metal coordinating and redox properties to the already demonstrated capability of these ligands to influence the angiogenesis and apoptosis processes.

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“…Sulfonamide have long been used as drugs for diseases, like leprosy, dysentery, gonorrhea, cold and pneumonia. Some of these drugs are showed biological activities when administered in the form of azomethines [4][5][6][7] . However azomethine containing derivatives of sulfanilamide and sulfathiazole are limited [8][9][10] .…”

Section: Introductionmentioning

confidence: 99%

Biological studies on derivatives of sulfanilamide and sulfathiazole

2016

Int. J. Curr. Res. Chem. Pharm. Sci

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Derivatives of sulfanilamide and sulfathiazole were prepared and characterised by analytical data, IR, 1 HNMR, 13 CNMR and UVVis spectra and screened for antibacterial activities against gram -positive bacteria Staphylococcus aureus and gram -negative bacteria Escherichia coli, Klebsiella aerogenes and Bacillus subtilis and antifungal activities against Aspergillus niger and Candida albicans by disc diffusion method. Ciprofloxacin and Nystatin were used as standard drug for bacteria and fungi.

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Synthesis, antibacterial, antifungal and anti-HIV activities of Schiff and Mannich bases derived from isatin derivatives and N-[4-(4′-chlorophenyl)thiazol-2-yl] thiosemicarbazide

Cited by 540 publications

References 6 publications

3-Hydroxy-3-(2-oxo-2,3-dihydro-1H-indol-3-yl)-2,3-dihydro-1H-indol-2-one

3-Hydroxy-3-(2-oxo-2,3-dihydro-1H-indol-3-yl)-2,3-dihydro-1H-indol-2-one

Oxindoles and copper complexes with oxindole-derivatives as potential pharmacological agents

Biological studies on derivatives of sulfanilamide and sulfathiazole

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