2023
DOI: 10.3390/ph16040517
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Synthesis, Anticancer, Antimicrobial and Antioxidant Potential of Novel 4-(Substituted phenyl-1,3,4-oxadiazol/thiadiazol-2-yl)-4-(4-substituted phenyl) Azetidin-2-One Derivatives

Abstract: By exploiting the ample biological potential of 1,3,4-oxadiazole/thiadiazole ring, 4-substitutedphenyl-1,3,4-oxadiazol/Thiadiazol-2-yl)-4-(4-substitutedphenyl) azetidin-2-one derivatives were prepared. Various substituted azetidin-2-one derivatives have been identified as immunostimulating and antimicrobial, as well as their antioxidant activity. 2-amino 1,3,4 oxadiazole/thiadiazole conjugates were synthesized by mixing semi/thio carbazides and sodium acetate with water and stirring well, followed by adding al… Show more

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Cited by 5 publications
(2 citation statements)
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“…An antioxidant assay based on a chain-breaking mechanism, such as DPPH, is one of the most commonly used methods of evaluating a compound’s antioxidant potential. Free radicals such as DPPH can be transformed into diamagnetic molecules by accepting hydrogen or electron radicals from antioxidants [ 29 ]. An absorption band at 517 nm is observed for the DPPH solution (methanolic).…”
Section: Resultsmentioning
confidence: 99%
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“…An antioxidant assay based on a chain-breaking mechanism, such as DPPH, is one of the most commonly used methods of evaluating a compound’s antioxidant potential. Free radicals such as DPPH can be transformed into diamagnetic molecules by accepting hydrogen or electron radicals from antioxidants [ 29 ]. An absorption band at 517 nm is observed for the DPPH solution (methanolic).…”
Section: Resultsmentioning
confidence: 99%
“…It is a colorimetric assay and is based on the reduction of the yellow tetrazolium salt, i.e., MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide), into a purple formazan product through active mitochondria. The number of active cells present is directly proportional to the total quantity of MTT cleaved, and its quantification is achievedby measuring the absorbance using a colorimeter [ 31 ]. This assay was carried out atDeshpande Laboratories (BMG FLUOstar microplate reader), Bhopal (Madhya Pradesh, (India) [ 32 ].…”
Section: Methodsmentioning
confidence: 99%