Synthesis, antimi crobial and anti-tuberculosis activities of some novel quinazolinone an a logues

Design, synthesis, in-silico studies and apoptotic activity of novel amide enriched 2-(1H)- quinazolinone derivatives

“…The quinazoline moiety serves as a fundamental structural unit in various physiologically active chemicals and medicinal molecules [ 18 ]. Quinazoline and quinazolinone derivatives have been attracted by biologists and medicinal chemists due to their diverse pharmacological activities [ 19 , 20 ], including anticancer [ [21] , [22] , [23] , [24] ], antitubercular [ [25] , [26] , [27] ], antimalarial [ 28 ], anti-inflammatory [ 29 , 30 ], antimicrobial [ 31 ], anticonvulsant [ 32 ], antihypertensive [ 33 , 34 ], antidiabetic [ 35 ], anti-HIV [ 36 ], antitumor [ [37] , [38] , [39] ], antioxidant [ 40 ], antiviral [ 41 ], kinase inhibitory [ 42 ], sedative-hypnotic, antihistaminic and many other uses [ 43 ]. Quinazoline and its derivatives are promising cancer chemotherapeutic agents for treating solid tumors [ [44] , [45] , [46] , [47] , [48] , [49] , [50] ].…”

Synthesis and characterization of Schiff bases derived from 3-aryl-2-formyl-4(3H)-quinazolinone

“…Quinazolinone analogues are versatile classes of nitrogen containing heterocycles that represent privileged scaffolds in synthetic chemistry and pharmacology. Many derivatives based on the quinazolinone system have attracted the great consideration of chemists and pharmacologists due to the wide range of biological activity of these compounds such as anticonvulsant [1,2], antiinflammatory [3],…”