Synthesis, antimicrobial and antioxidant activities of some new indole derivatives containing pyridopyrimidine and pyrazolopyridine moieties

Magnetically Recyclable Nano-FDP: A Novel, Efficient Nano-Organocatalyst for the One-Pot Multi-Component Synthesis of Pyran Derivatives in Water Under Ultrasound Irradiation

“…According to proposed mechanism, firstly ethyl acetoacetate (11) reacts instantly with hydrazine hydrate (10) or phenyl hydrazine (14) leading to the formation of pyrazolone derivatives (15a,b). Then, in the second step nano-FDP binds with aldehyde forming iminium intermediate (16) which reacts with malononitrile (9) in Knoevengel fashion to give cyano-olefin compound (18). Finally nano-FDP catalyzes the formation of intermediate (19) which undergoes intermolecular cyclization to afford desired product (12 or 13).…”

“…1) like anti-tumour, anti-cancer, anti-microbial, anti-oxidant, anti-proliferative, anti-inflammatory, anti-HIV, anti-tumour, analgesics etc. [14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30]. On continuing our exploration for synthesis and application of different nanoparticles in multi-component reactions [31], we herein report a novel method for synthesis of nano-Fe 3 O 4 -DOPA-L-proline (nano-FDP) which shows extraordinary catalytic activity in one-pot, multi-component synthesis of pyran derivatives under ultrasonic irradiation.…”

Microwave-Assisted Synthesis of Bioactive Six-Membered Heterocycles and Their Fused Analogues

“…For example, this system is present in AZD8055 (180), a selective ATP-competitive PI3KAkt-mTOR signaling pathway inhibitor [168], piritrexim (181), a lipid-soluble inhibitor of dihydrofolate reductase (DHFR) that displays high potency for the treatment of metastatic urothelial cancer [169], and pyrido[2,3-d]pyrimidine 182 that is a hepatitis C virus inhibitor [170] (Figure 12). Other pyridopyrimidine derivatives have also been reported for their potential use as anticardiovascular [171], anti-inflammatory [172,173], antibacterial [174,175], and anti-Parkinson agents [176]. In this context, novel series of pyridopyrimidines were synthesized by Basiri et al [177] through a one pot four-component MW-assisted reaction.…”

In vitro antiproliferative/cytotoxic activity of 2,3ʹ-biindole againstvarious cancer cell lines

“…Bromination of indole poses a dimeric product (2; Figure 1); as a result, 3-haloindoles and 2-haloindoles are unstable structures (Robertson et al, 2000;Joule and Mills, 2010;Kianmehr et al, 2012). Since the dimeric structures can react with transition metals as ligands in order to give metal complexes, they have high potential for use in catalytic processes (Omura et al, 1977;Black, 1993;Saundane et al, 2013).…”