Synthesis, Antimicrobial and In Silico EGFR Inhibitory Activity Evaluation of Sulfonylamino Pyrrolidine Derivatives

Kumar, B. Santosh; Prasad, A. Raghavendra Guru; Ravindranath, L. K.

doi:10.1007/s11094-016-1467-1

Cited by 5 publications

(3 citation statements)

References 17 publications

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“…Three other naturally occurring pyrrolidine alkaloids, namely, acanthophoraine A 80 , acanthophoraine B 81 , and acanthophoraine C 82 , were isolated from a red alga called Acanthophora spicifera , and their antibacterial activities were screened against the bacterial strains, including E. faecalis , S. aureus , P. aeruginosa , K. pneumoniae , A. baumannii , and E. coli , and no desirable effects were found on the tested bacteria ( Lin et al, 2020 ; Guan et al, 2021 ).…”

Section: Natural Sources Containing the Pyrrolidine Ringmentioning

confidence: 99%

“…The results of the research revealed that altering the coordinating groups of the ligands enhanced their antiproliferative activity. Kumar et al (2016) synthesized sulfonylamino pyrrolidine derivatives and evaluated their in silico EGFR potential as well as their antibacterial and antifungal activities. Antibacterial activity studies were compared with those of reference cefaclor against S. aureus, E. coli, and P. aeruginosa bacteria.…”

Section: Polysubstituted Pyrrolidinesmentioning

confidence: 99%

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Recent insights about pyrrolidine core skeletons in pharmacology

Poyraz,

Döndaş,

Döndaş

et al. 2023

Front. Pharmacol.

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To overcome numerous health disorders, heterocyclic structures of synthetic or natural origin are utilized, and notably, the emergence of various side effects of existing drugs used for treatment or the resistance of disease-causing microorganisms renders drugs ineffective. Therefore, the discovery of potential therapeutic agents that utilize different modes of action is of utmost significance to circumvent these constraints. Pyrrolidines, pyrrolidine-alkaloids, and pyrrolidine-based hybrid molecules are present in many natural products and pharmacologically important agents. Their key roles in pharmacotherapy make them a versatile scaffold for designing and developing novel biologically active compounds and drug candidates. This review aims to provide an overview of recent advancements (especially during 2015–2023) in the exploration of pyrrolidine derivatives, emphasizing their significance as fundamental components of the skeletal structure. In contrast to previous reviews that have predominantly focused on a singular biological activity associated with these molecules, this review consolidates findings from various investigations encompassing a wide range of important activities (antimicrobial, antiviral, anticancer, anti-inflammatory, anticonvulsant, cholinesterase inhibition, and carbonic anhydrase inhibition) exhibited by pyrrolidine derivatives. This study is also anticipated to serve as a valuable resource for drug research and development endeavors, offering significant insights and guidance.

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Section: Natural Sources Containing the Pyrrolidine Ringmentioning

confidence: 99%

Section: Polysubstituted Pyrrolidinesmentioning

confidence: 99%

Recent insights about pyrrolidine core skeletons in pharmacology

Poyraz,

Döndaş,

Döndaş

et al. 2023

Front. Pharmacol.

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“…Thus, two related papers examine the antibacterial activity of bis(thiophene‐2‐sulfonamides) derived from 3,4‐diaminopyrrolidines. In the first report, [ 277 ] the synthesis of these sulfonamides was achieved in two steps, namely, the Curtius rearrangement of 2‐[(3 S ,4 S )‐3,4‐diaminopyrrolidin‐1‐yl]acetyl azide in the presence of less common alcohols, followed by sulfonylation of the resulting of five carbamates with thiophene‐2‐sulfonyl chloride. In this series, sulfonamides 304 (X = O or S) (Figure 36) had broad antibacterial activity (they were approximately three times less potent than cefaclor against S. aureus , E. coli and P. aeruginosa ) and antifungal activity (they were approximately eleven times less potent than ketoconazole against A. niger and more than 25 times less potent than ketoconazole against C. albicans ), while the antimicrobial activity of the remaining three thiophenes in the series was poor.…”

Section: Antimicrobial Activity Of Miscellaneous Thiophenesmentioning

confidence: 99%

Thiophene‐containing compounds with antimicrobial activity

Roman¹

2022

Archiv der Pharmazie

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Thiophene, as a member of the group of five-membered heterocycles containing one heteroatom, is one of the simplest heterocyclic systems. Many synthetic strategies allow the accurate positioning of various functionalities onto the thiophene ring. This review provides a comprehensive, systematic and detailed account of the developments in the field of antimicrobial compounds featuring at least one thiophene ring in their structure, over the last decade.

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