Synthesis, antimicrobial, antioxidant, anti-hemolytic and cytotoxic evaluation of new imidazole-based heterocycles

Abdel‐Wahab, Bakr F.; Awad, Ghada E. A.; Badria, Farid A.

doi:10.1016/j.ejmech.2011.01.062

Cited by 140 publications

(50 citation statements)

References 31 publications

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“…There are many compounds bearing this fragment which are used in therapy, for treating inflammation [16], oxidative stress [17,18], bacterial infections [19][20][21], hyperglycemia, hyperlipidemia [22], cancer [23][24][25], schizophrenia, hypertension, HIV infection, hypnotics, allergy, etc.…”

Section: Open Accessmentioning

confidence: 99%

New Hydrazones Bearing Thiazole Scaffold: Synthesis, Characterization, Antimicrobial, and Antioxidant Investigation

et al. 2015

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New series of hydrazones 5-18 were synthesized, in good yields, by reacting 4-methyl-2-(4-(trifluoromethyl)phenyl)thiazole-5-carbohydrazide with differently substituted benzaldehyde. The resulting compounds were characterized via elemental analysis, physico-chemical and spectral data. An antimicrobial screening was done, using Gram (+), Gram (−) bacteria and one fungal strain. Tested molecules displayed moderate-to-good growth inhibition activity. 2,2-Diphenyl-1-picrylhydrazide assay was used to test the antioxidant properties of the compounds. Monohydroxy (14-16), para-fluorine (13) and 2,4-dichlorine (17) derivatives exhibited better free-radical scavenging ability than the other investigated molecules.

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Section: Open Accessmentioning

confidence: 99%

New Hydrazones Bearing Thiazole Scaffold: Synthesis, Characterization, Antimicrobial, and Antioxidant Investigation

et al. 2015

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“…Linear free energy relationships (LFER) were applied to the 1 H-NMR spectral data of compounds 7-13 and IR spectral. A variety of substituents were employed for phenyl substitution and fairly good correlations were obtained using the simple Hammett and the Hammett-Taft dual substituent parameter equations [25,26]. The correlation results of the substituent induced 1 H-NMR chemical shifts (SCS) of the CH3 at C5 isoxazole spins indicated different sensitivity with respect to electronic substituent effects.…”

Section: Spectroscopic Examinationmentioning

confidence: 99%

Understanding Chemistry and Unique NMR Characters of Novel Amide and Ester Leflunomide Analogues

et al. 2017

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A series of diverse substituted 5-methyl-isoxazole-4-carboxylic acid amides, imide and esters in which the benzene ring is mono or disubstituted was prepared. Spectroscopic and conformational examination was investigated and a new insight involving steric interference and interesting downfield deviation due to additional diamagnetic anisotropic effect of the amidic carbonyl group and the methine protons in 2,6-diisopropyl-aryl derivative (2) as conformationaly restricted analogues Leflunomide was discussed. Individual substituent electronic effects through π resonance of p-substituents and most stable conformation of compound (2) are discussed.

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“…Hydrazones are of wide interest because of their diverse biological applications such as anticonvulsant, antidepressant, analgesic, anti-inflammatory, antiplatelet, antimalarial, antimicrobial, antimycobacterial, anticancer, vasodilator, antiviral, anti-HIV, anthelmintic, antidiabetic, and trypanocidal activities [2][3][4][5][6][7][8][9][10].…”

Section: Introductionmentioning

confidence: 99%

Analgesic, Anti-Inflammatory, and Antiplatelet Profile of Hydrazones Containing Synthetic Molecules

Asif

Husain

2013

Journal of Applied Chemistry

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Hydrazones are present in many of the bioactive compounds with wide interest because of their diverse pharmacological applications. Hydrazones possess wide variety of biological activities such as anticonvulsant, antidepressant, analgesic, anti-inflammatory, antiplatelet, antimicrobial, anticancer, antihypertensive, anthelmintic, antidiabetic, antiparasitic, and other anticipated activities. This created an interest for researchers towards synthesized variety of hydrazone derivatives for different biological activities. Therefore many researchers have synthesized hydrazone derivatives as target structures for their biological activities. This is paper focuses on the analgesic, anti-inflammatory, and antiplatelet activities of hydrazones.

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Synthesis, antimicrobial, antioxidant, anti-hemolytic and cytotoxic evaluation of new imidazole-based heterocycles

Cited by 140 publications

References 31 publications

New Hydrazones Bearing Thiazole Scaffold: Synthesis, Characterization, Antimicrobial, and Antioxidant Investigation

New Hydrazones Bearing Thiazole Scaffold: Synthesis, Characterization, Antimicrobial, and Antioxidant Investigation

Understanding Chemistry and Unique NMR Characters of Novel Amide and Ester Leflunomide Analogues

Analgesic, Anti-Inflammatory, and Antiplatelet Profile of Hydrazones Containing Synthetic Molecules

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