Synthesis, antimicrobial, antiquorum-sensing, antitumor and cytotoxic activities of new series of fused [1,3,4]thiadiazoles

Antimicrobial and Antiquorum‐Sensing Studies. Part 3: Synthesis and Biological Evaluation of New Series of [1,3,4]Thiadiazoles and Fused [1,3,4]Thiadiazoles

“…In addition, thiazolidin-3-yl- [1,3,4]-thiadiazoles were extensively investigated for their pharmacological uses, some of these compounds showed antimicrobial activity [40][41][42][43][44]. Considering these published data and in continuation to our previous work [15,16] and in searching for new compounds of potent antimicrobial and antiquorumsensing activities, we described herein the synthesis of new series of [1,3,4]thiadiazoles and fused [1,3,4]thiadiazoles. The synthesized compounds were evaluated for their antibacterial, antifungal, antiquorum-sensing, and in vitro cytotoxic activities as well as in vivo acute toxicity and DNA-binding affinity.…”

“…Regarding Scheme 3, heating amine 1 with ethyl chloroacetate in glacial acetic acid gave the imidazo [2,1-b] [1,3,4]thiadiazole derivative 8 [16]. Condensation of 8 with the appropriate diazonium chloride 9a,b (obtained in situ by diazotization of the appropriate aniline using a mixture of sodium nitrite and hydrochloric acid in the presence of sodium acetate) produced 5-(4-substituted phenyl)hydrazono-5H-imidazo [2,1-b] [1,3,4]thiadiazole derivatives 10a,b.…”

“…Literature survey revealed that [1,3,4]thiadiazolo [3,2-a]pyrimidine nucleus is associated with diverse pharmacodynamic and chemotherapeutic activities [15][16][17][18][19][20][21][22][23][24][25][26]. Moreover, many imidazo- [2,1-b] [1,3,4]thiadiazole derivatives are known to possess interesting pharmacological properties, including antibacterial [27][28][29][30][31], antifungal [32], and antimicrobial [16,[33][34][35] activities.…”

“…Moreover, many imidazo- [2,1-b] [1,3,4]thiadiazole derivatives are known to possess interesting pharmacological properties, including antibacterial [27][28][29][30][31], antifungal [32], and antimicrobial [16,[33][34][35] activities. The arylideneamino- [1,3,4]thiadiazoles possess antimicrobial activity [36][37][38][39].…”

Synthesis and antimicrobial activity evaluation of novel nitrofuranthiazoles

“…Many antibacterial agents are in use against a wide range of infectious diseases 1,2 . However, the resistance to existing drugs is still a serious problem threat to global public health.…”