Synthesis, antitumor activity, 3D-QSAR and molecular docking studies of new iodinated 4-(3<i>H</i>)-quinazolinones 3<i>N</i>-substituted

A gold(I)-catalyzed cascade intramolecular cyclization of Ugi adducts for the divergent construction of quinazolinone and ampakine analogues has been developed in a rapid, highly efficient and step-economical manner. This protocol shows high yields, excellent functional-group tolerance, broad substrate scope and excellent chemo-and regioselectivity. The practicality of this strategy is further demonstrated by a scale-up reaction. Diverse oligopeptides are also found to be well tolerated, affording polycyclic products decorated with a peptide chain. Letter pubs.acs.org/OrgLett

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Synthesis and Identification of Some New Heterocyclic Compounds Derived from N-(6-Hydrazinyl-6-oxohexanoyl)phthalimide

Ali,

Al-Tamimi,

Alrecabi

2024

Russ J Org Chem

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Synthesis, antitumor activity, 3D-QSAR and molecular docking studies of new iodinated 4-(3H)-quinazolinones 3N-substituted

Abstract: New iodinated 4-(3H)-quinazolinones 3N-substituted with antitumor activity and 3D-QSAR and molecular docking studies as dihydrofolate reductase (DHFR) inhibitors.

Cited by 3 publications

References 119 publications

Efficient synthesis and molecular docking analysis of quinazoline and azole hybrid derivatives as promising agents for anti-cancer and anti-tuberculosis activities

Efficient synthesis and molecular docking analysis of quinazoline and azole hybrid derivatives as promising agents for anti-cancer and anti-tuberculosis activities

Gold(I)-Catalyzed Intramolecular Bicyclization: Divergent Construction of Quinazolinone and Ampakine Analogues

Synthesis and Identification of Some New Heterocyclic Compounds Derived from N-(6-Hydrazinyl-6-oxohexanoyl)phthalimide

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Synthesis, antitumor activity, 3D-QSAR and molecular docking studies of new iodinated 4-(3H)-quinazolinones 3N-substituted

Abstract: New iodinated 4-(3H)-quinazolinones 3N-substituted with antitumor activity and 3D-QSAR and molecular docking studies as dihydrofolate reductase (DHFR) inhibitors.

Cited by 3 publications

References 119 publications

Efficient synthesis and molecular docking analysis of quinazoline and azole hybrid derivatives as promising agents for anti-cancer and anti-tuberculosis activities

Efficient synthesis and molecular docking analysis of quinazoline and azole hybrid derivatives as promising agents for anti-cancer and anti-tuberculosis activities

Gold(I)-Catalyzed Intramolecular Bicyclization: Divergent Construction of Quinazolinone and Ampakine Analogues

Synthesis and Identification of Some New Heterocyclic Compounds Derived from N-(6-Hydrazinyl-6-oxohexanoyl)­phthalimide

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Synthesis and Identification of Some New Heterocyclic Compounds Derived from N-(6-Hydrazinyl-6-oxohexanoyl)phthalimide