Synthesis, antiviral and anticancer activity of some novel thioureas derivedfrom N-(4-nitro-2-phenoxyphenyl)-methanesulfonamide

Tiyoüreler, açiltiyoüreler ve 4-tiyazolidinonların sentezi, karakterizasyonu ve antikanser ve antiviral etkilerinin değerlendirilmesi

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ABSTRACTIn this study, thiourea derivatives [1][2][3][4] were synthesized by using 2-amino-4-substituted pyridine compounds and these compounds have been used as the starting materials for synthesis of 2-imino-1,3-thiazolidin-4-one ring [5,6]. Two different procedures for 4-thiazolidinone ring closure and synthesis method were optimized.

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Antimicrobial and Anti-biofilm Activity of Thiourea Derivatives Incorporating a 2-Aminothiazole Scaffold

“…Due to the previously reported anti-HIV activities of thiourea derivatives, 24,25) title compounds were tested in the cellbased assay against the human immunodeficiency virus type-1 (HIV-1), using Efavirenz as reference inhibitor. The cytotoxicity against the MT4 cells was evaluated in parallel with the antiviral activity (Table 5).…”

Synthesis and evaluation of antiviral, antitubercular and anticancer activities of some novel thioureas derived from 4-aminobenzohydrazide hydrazones

“…Sriram and co-workers have recently reported antitubercular activity of several thiourea derivatives obtained from isonicotinoyl hydrazone (6). Antitumor (7,8) and antitubercular (9-11) activities of some hydrazide-hydrazones and thioureas have been reported. In addition, some thiourea derivatives were reported to be potent inhibitors of influenza virus neuraminidase, Coxsackie B4 virus and thymidine kinase positive varicellazoster virus (TK + VZV, OKA strain) (12,13).…”