Synthesis approaches of amphiphilic copolymers for spherical micelle preparation: application in drug delivery

Abstract

The formation of polymeric micelles in aqueous environments through the self-assembly of amphiphilic polymers can provide a versatile platform to increase the solubility and permeability of hydrophobic drugs and pave...

Formation of Amphiphilic Zwitterionic Thin Poly(SBMA-co-TFEMA) Brushes on Solid Surfaces for Marine Antifouling Applications

“…Amphiphilic polymers, which contain both hydrophilic and hydrophobic components, are of considerable interest in various fields owing to their ability to adsorb at interfaces and self-assemble into aggregates . These polymers are widely applied in biotechnology, detergents, agriculture, cosmetics, food, electronics, and pharmaceuticals. − Furthermore, by incorporating both hydrophobic and zwitterionic components into polymer coatings, the surface can be rendered “ambivalent” to marine biofoulants, thereby inhibiting biofouling. , Amphiphilic zwitterionic polymer coatings are also less prone to sediment adsorption than zwitterionic polymer coatings owing to the decreased fraction of the zwitterionic components, which tend to adsorb sediments . Thus, amphiphilic zwitterionic polymers are promising as antifouling coating materials that can overcome the limitations of zwitterionic polymers .…”

Degradable Polymer-Based Nanoassemblies for Precise Targeting and Drug Delivery to Breast Cancer Cells without Affecting Normal Healthy Cells

“…Supramolecular assemblies of amphiphilic polymers − have been of great interest because of their potential utility in the field of biomedical sciences including drug delivery, − gene delivery, , cell imaging, − tissue engineering, − etc. Polymeric material-based nanoassemblies such as micelles, − vesicles, − and liposomes − are widely used as drug carriers due to their enhanced kinetic and thermodynamic stability compared to small-molecule-based assemblies. They hold the promise to keep the sequestered drug molecules safe under one set of conditions and release them under another in response to physiological stimuli such as pH, − light, − hypoxia, − redox, − temperature, − enzymes, , etc.…”

Novel amphiphilic (AB)3‐type star block polymer: Synthesis and micellization study

“…Studying the micellization phenomenon of amphiphilic star polymers has always been of great importance because of their high potential in the preparation of various drug delivery systems. [1][2][3][4][5] Micellization is a phenomenon that is completely dependent on the chemical structure of the amphiphilic polymer. The average diameter of the micelles and the minimum concentration of the polymer in the aqueous solution that leads to the formation of micelles are closely related to the contribution of the hydrophilic and hydrophobic segments in the structure.…”