Synthesis, Biological Activities, Antioxidant Properties, and Molecular Docking Studies of Novel Bis-Schiff Base Podands as Responsive Chemosensors for Anions

Yapar, Gönül; Demir, Neslihan; Kiraz, Aşkın; Yalçın, Gözde; Yıldız, Mustafa

doi:10.1016/j.molstruc.2022.133530

Cited by 16 publications

(12 citation statements)

References 49 publications

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“…Spectral data and elemental analysis conrmed the structures of the synthesized isatin-based azomethine derivatives 2a, 2b, and 3a-d. Bis-Schiff bases are famous for their antitumor, antioxidant, antiglycation, antibacterial, and antiviral activities. [44][45][46] Also, act as inhibitors of enzymes such as a-glucosidase, 47 butrylcholinesterase, and acetylcholinesterase. 48 As shown in Scheme 3, the reaction was readily extended to synthesize a new bis-Schiff base by reaction of 3-hydrazonoindolin-2-one (1) with various bis-aldehyde.…”

Section: Chemistrymentioning

confidence: 99%

Exploring novel derivatives of isatin-based Schiff bases as multi-target agents: design, synthesis,in vitrobiological evaluation, andin silicoADMET analysis with molecular modeling simulations

2023

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Section: Chemistrymentioning

confidence: 99%

Exploring novel derivatives of isatin-based Schiff bases as multi-target agents: design, synthesis,in vitrobiological evaluation, andin silicoADMET analysis with molecular modeling simulations

2023

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“…During the stage of chain propagation, the H atom from the phenolic hydroxyl group of the antioxidant combines with the generated peroxide radical ROO•, forming hydroperoxide ROOH (i.e., a stable radical). Furthermore, it combines with the radical (generated in the stage of chain propagation) and forms a stable compound, leading to termination of the reaction. − The chemical reactions are as follows: ArOH + ROO• → ROOH + ArO• ArO• + ROO• → ROOArO ArO• + R• → ArOR …”

Section: Introductionmentioning

confidence: 99%

Antimigration Polypropylene Antioxidants: A Review

Li,

Zhang,

Jiang

et al. 2024

Ind. Eng. Chem. Res.

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Hindered phenolic antioxidants have been extensively recognized and applied to boost the heat resistance and oxidative aging performance of poly(propylene) (PP) composites. Low-molecular-weight antioxidants are easy to volatilize, migrate, and be extracted from PP or PP-based products, which can directly reduce the antithermal oxidative aging effect of PP and its composites, and it can contaminate food or drugs under its packaging. The design of an efficient and durable antioxidant with antimigration performance has drawn the attention of researchers. Currently, three main approaches are explored: (I) enhancement of molecular weight, that is, high molecular weight of antioxidants can stimulate the structure stability and the resistance toward migration; (II) inorganic immobilization, which involves immobilizing the antioxidants on inorganic substrate to enhance the dispersion and the antimigration performance; and (III) intercalation-mediated assembly, which involved intercalating low-molecular-weight antioxidants into the interlayer region of a layered host to boost antimigration performance based on the host–guest interaction.

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“…Therefore, we focused on the properties of linear-type host molecules − and studied a selective inclusion method using open-chain-type host molecules with a 2,2′-thiodiphenol moiety, which is a partial structure of p - tert -butylthiacalix[4]arene. − Carboxylic acid-type hosts, such as compound 1 , can selectively include aromatic amine isomers via the formation of salt complexes with pseudocyclic structures (Chart ). , In the crystal, compound 1 , in which two phenolic moieties adopt an anti conformation, forms a one-dimensional chain through hydrogen bonds among the carboxy groups, and these chains are stacked to form a sheet structure.…”

Section: Introductionmentioning

confidence: 99%

Selective Inclusion of Cyclohexanediol Stereoisomer by Crystals of Open-Chain Diol-Type Host Based on a Partial Structure of p-tert-Butylthiacalixarene

Morohashi,

Suzuki,

Ogihara

et al. 2024

Crystal Growth & Design

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For the efficient separation of hard-to-separate organic molecule isomers, the creation of solid materials that can distinguish between isomers and selectively collect them is important. For example, in the separation of organic molecule isomers that have multiple functional groups such as hydroxy groups, the design of host molecules that allow the precise recognition of the positions and orientations of the functional groups is required. In this study, based on sulfur-bridged phenol dimer that is a partial structure of p-tert-butylthiacalixarene, an open-chain diol-type host 2 was designed and synthesized. In compound 2, two phenolic hydroxy groups were bridged with a methylene group to fix the conformation, and two alcoholic hydroxy groups were introduced for guest recognition sites. In a competitive inclusion experiment from an aqueous solution of a cis/trans mixture of 1,3-cyclohexanediol, crystals of host 2 selectively included cis-isomer. The isomer selectivity was low for the inclusion of 1,2-diol, and 1,4-diol was not included. X-ray crystallographic analysis of the inclusion complex of host 2, which predominantly included the cis-isomer of 1,3-diol, revealed that two hydroxy groups of the host form cooperative hydrogen bonds with two hydroxy groups of the guest. The results show that densely packed stable crystals can be formed by fixing the conformation of the host to construct an inclusion space and by the precise recognition of the guest functional groups complementary to the host molecule. This study provides an approach for the design of host molecules that can selectively include difficult-to-separate target molecules.

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Synthesis, Biological Activities, Antioxidant Properties, and Molecular Docking Studies of Novel Bis-Schiff Base Podands as Responsive Chemosensors for Anions

Cited by 16 publications

References 49 publications

Exploring novel derivatives of isatin-based Schiff bases as multi-target agents: design, synthesis,in vitrobiological evaluation, andin silicoADMET analysis with molecular modeling simulations

Exploring novel derivatives of isatin-based Schiff bases as multi-target agents: design, synthesis,in vitrobiological evaluation, andin silicoADMET analysis with molecular modeling simulations

Antimigration Polypropylene Antioxidants: A Review

Selective Inclusion of Cyclohexanediol Stereoisomer by Crystals of Open-Chain Diol-Type Host Based on a Partial Structure of p-tert-Butylthiacalixarene

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