Synthesis, biological evaluation, and docking studies of various β‐substituted porphyrin conjugates embedded with N‐containing heterocycles

Abstract

A new methodology for the synthesis of some new β‐porphyrin heterocyclic compounds containing nitrogen derivatives 10, 12, 13, 15, 17, 19, 21, 22, 25, 27, and 29 was screened for their cytotoxic activities. Both elemental and spectral analyses were used to confirm the structures of new compounds. Compounds 22, 27, and 21 exhibited very strong activity against the HepG2 cell line. Investigation of the binding between porphyrin 22 and the binding site of telomerase was performed by molecular docking.

A decade's overview of 2‐aminothiophenes and their fused analogs as promising anticancer agents

“…Masaret synthesized a novel series having 2‐phenylaminothiophene scaffold and evaluated their cytotoxic activity. [ 124 ] Compounds 52a–c and 53a–c showed potent anticancer activity against HepG2 and PC3 cell lines with IC 50 values ranging from 3.94 to 20.48 µM. According to SAR studies, the addition of p ‐chloro on the phenyl ring or pyran ring in 52c and 53c respectively increases the cytotoxic activity.…”