Synthesis, biological evaluation, and molecular docking of ropivacaine analogs as local anesthetic agents

Deep simulated annealing for the discovery of novel dental anesthetics with local anesthesia and anti-inflammatory properties

“…A sciatic nerve block model 37 , 38 , 39 was used to evaluate and compare the nerve-blocking effects of AT and its derivatives. After injection into the sciatic nerve of rats, sensory and motor functions were assessed using the hotplate test and extensor postural thrust (EPT) reaction test.…”

Efficacy of Ropivacaine for Sub-Arachnoid Block in Patients with Recent History of Scorpion Sting

“…The aromatic part of ropivacaine aligns towards the outer side of VGSC whereas the aromatic part of bupivacaine aligns towards the inner side of the channel. 12 , 13 This differential alignment of the aromatic ring may contribute to the difference in resistance of the two LA caused by scorpion sting. Furthermore, action of ropivacaine on gamma aminobutyric acid A and N-methyl-D-aspartate receptors, facilitates its LA action, thereby decreasing the chances of its resistance in patients with a scorpion sting.…”