Synthesis, biological evaluation and molecular docking studies of 3-(triazolyl)-coumarin derivatives: Effect on inducible nitric oxide synthase

Rational Design, Synthesis and Evaluation of Coumarin Derivatives as Protein‐protein Interaction Inhibitors

“…It is well‐known that coumarins are a versatile class of heterocycles displaying a wide range of therapeutic activities. Particularly, coumarin derivatives have been shown to be pharmacologically useful as anti‐coagulants, anti‐oxidants, antitumorals, free radical scavengers and also anti‐HIV agents …”

Insights on the vasorelaxant mode of action of malbrancheamide

“…Since the identification of nitric oxide (NO) as the endothelium‐derived relaxing factor, its role as secondary intra‐ and intercellular messenger in several physiological and pathophysiological conditions has been thoroughly investigated [1,2]. NO is physiologically produced by the catalysis of nitric oxide synthases (NOS), which are Ca 2+ ‐calmodulin (CaM)‐dependent enzymes [3]. There are three NOS isoforms, i NOS (inducible), n NOS (neuronal) and e NOS (endothelial), which are homodimeric, with each monomer containing an N‐terminal oxygenase and a C‐terminal reductase domain, connected by a CaM‐binding site [4].…”

Coumarin heterocyclic derivatives: chemical synthesis and biological activity

“…This compound is further treated with various organic azides via a CuI-promoted reaction in the presence of PMDTA as a ligand (Scheme 44). 118 In general, the alkyl azides gave lower yields, whilst the electronrich and neutral aryl azides gave high yields of the 1,2,3-triazoles.…”