Synthesis, biosynthesis and biological activities of galbanic acid – A review

Abstract

Context: Galbanic acid

Galbanic acid inhibits HIF-1α expression via EGFR/HIF-1α pathway in cancer cells

“…Galbanic acid showed inhibitory effects on tumors cell proliferation, and induces cell apoptosis in vitro in limited previous investigation [51]. GBA significantly decrease vascular endothelial growth factor (VEGF) that accompanied by inactivation of p38-mitogen-activated protein kinase (MAPK).…”

Modulation of Multidrug Resistance Protein 2 Efflux in the Cisplatin Resistance Human Ovarian Carcinoma Cells A2780/RCIS by Sesquiterpene Coumarins

“…SCs from the genus Ferula have shown versatile biological activities. To our knowledge, the effects of SCs on the inhibition of ABC transporters have been the most remarkable biological activities of SCs (Esmail Nazari and Iranshahi, ; Kasaian et al , ; Hanafi‐Bojd et al , ).…”

“…Fourteen SCs (HPLC, purity >95%) were isolated from the roots of different Ferula species according to previous methods. Mogoltacin and mogoltadone were isolated from F. flabelliloba (Iranshahi et al, 2010a); galbanic acid, umbelliprenin, farnesiferol B, farnesiferol C, lehmferin, and microlobin were isolated from F. szowitsiana (Iranshahi, 2012); farnesiferol A had been isolated from Ferula persica previously (Iranshahi et al, 2004); conferone, conferdione, and gumoside B were isolated from F. gummosa (Iranshahi et al, 2010b); samarcandin and mogoltavidin were isolated from F. galbaniflua (Kasaian et al, 2014a). The chemical structures of SCs isolated from Ferula species are shown in Fig.…”

“…SCs from the genus Ferula have shown versatile biological activities. To our knowledge, the effects of SCs on the inhibition of ABC transporters have been the most remarkable biological activities of SCs (Esmail Nazari and Iranshahi, 2011;Kasaian et al, 2014a;Hanafi-Bojd et al, 2011). Madureira et al reported that driportlandin, a SC ether of the drimane type from Euphorbia portlandica, had reversal activity on MDR in mouse lymphoma cells (Madureira et al, 2004).…”

“…Ferula species from the family Apiaceae are rich sources of biologically active natural products including sulphur-containing compounds (Mozaffarian, 1996;Iranshahi et al, 2003a;Iranshahi et al, 2006;Iranshahi, 2012), sesquiterpene coumarins (SCs) (Iranshahi et al, 2004;Iranshahi et al, 2010a;Iranshahi et al, 2010b;Esmail Nazari and Iranshahi, 2011;Kasaian et al, 2014a), and sesquiterpenes (Iranshahi et al, 2003b;Iranshahi et al, 2008;Kasaian et al, 2014b). Some studies showed that SCs were able to enhance the cytotoxicity of * anticancer compounds (Behnam Rassouli et al, 2009;Neshati et al, 2009;Rassouli et al, 2011).…”