Synthesis by microwave irradiation of new pyrazole-imidazoline-pyrimidine analogs: Physicochemical and photophysical properties and their biological activity against Trypanosoma cruzi

Pereira, Cynthia Nathalia; Rosa, J.; Lara, Leonardo da Silva; Orlando, Lorraine Martins Rocha; Figueiredo, Nataly Damasceno de; Pereira, Mirian Claudia de Souza; Nobuyasu, Roberto S.; Santos, Maurício Silva dos

doi:10.1016/j.molstruc.2023.135899

Journal of Molecular Structure

2023

DOI: 10.1016/j.molstruc.2023.135899

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Synthesis by microwave irradiation of new pyrazole-imidazoline-pyrimidine analogs: Physicochemical and photophysical properties and their biological activity against Trypanosoma cruzi

Cynthia Nathalia Pereira

J. Rosa

Leonardo da Silva Lara

et al.

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2024

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Efficient Synthesis and Iodine‐Functionalization of Pyrazoles via KIO₃/PhSeSePh System under Acidic Conditions

Peglow,

Thomaz,

Nobre

et al. 2024

Chemistry An Asian Journal

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This manuscript reports a novel method for the direct iodination of the C‐4 pyrazole ring generated in situ by the reaction of 1,1,3,3‐tetramethoxypropane and various hydrazines. In this approach, potassium iodate (KIO3) and (PhSe)2 are used as catalysts under acidic conditions. This protocol provides a convenient method for the efficient synthesis of 4‐iodo‐1‐aryl‐1H‐pyrazoles, valuable intermediates for several different coupling reactions.

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Efficient Synthesis and Iodine‐Functionalization of Pyrazoles via KIO₃/PhSeSePh System under Acidic Conditions

Peglow,

Thomaz,

Nobre

et al. 2024

Chemistry An Asian Journal

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show abstract

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Synthesis by microwave irradiation of new pyrazole-imidazoline-pyrimidine analogs: Physicochemical and photophysical properties and their biological activity against Trypanosoma cruzi

Cited by 1 publication

References 52 publications

Efficient Synthesis and Iodine‐Functionalization of Pyrazoles via KIO₃/PhSeSePh System under Acidic Conditions

Efficient Synthesis and Iodine‐Functionalization of Pyrazoles via KIO₃/PhSeSePh System under Acidic Conditions

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Synthesis by microwave irradiation of new pyrazole-imidazoline-pyrimidine analogs: Physicochemical and photophysical properties and their biological activity against Trypanosoma cruzi

Cited by 1 publication

References 52 publications

Efficient Synthesis and Iodine‐Functionalization of Pyrazoles via KIO3/PhSeSePh System under Acidic Conditions

Efficient Synthesis and Iodine‐Functionalization of Pyrazoles via KIO3/PhSeSePh System under Acidic Conditions

Contact Info

Product

Resources

About

Efficient Synthesis and Iodine‐Functionalization of Pyrazoles via KIO₃/PhSeSePh System under Acidic Conditions

Efficient Synthesis and Iodine‐Functionalization of Pyrazoles via KIO₃/PhSeSePh System under Acidic Conditions