2011
DOI: 10.1016/j.ejmech.2011.04.049
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Synthesis, cellular uptake, apopotosis, cytotoxicity, cell cycle arrest, interaction with DNA and antioxidant activity of ruthenium(II) complexes

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Cited by 63 publications
(8 citation statements)
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“…For these reason, ruthenium-based drugs are being developed and have offered potential advantages over the antitumor platinum(II) complexes including reduced toxicity, a novel mechanism of action, the prospect of no cross-resistance and a different spectrum of activity [12]. Several lines of evidence have indicated that ruthenium polypyridyl complexes inhibit the proliferation of cells by inhibiting cell proliferation, cell cycle progression and inducing apoptosis [16,19,45,46]. …”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…For these reason, ruthenium-based drugs are being developed and have offered potential advantages over the antitumor platinum(II) complexes including reduced toxicity, a novel mechanism of action, the prospect of no cross-resistance and a different spectrum of activity [12]. Several lines of evidence have indicated that ruthenium polypyridyl complexes inhibit the proliferation of cells by inhibiting cell proliferation, cell cycle progression and inducing apoptosis [16,19,45,46]. …”
Section: Discussionmentioning
confidence: 99%
“…It has been reported that the intracellular uptake is to a major extent determined by the carrier ligand [15,18]. The hydrophobicity of the ruthenium-based drugs could also minimize the impact of the decreased accumulation of resistance mechanisms [19]. It has been shown that NAMI-A [47] inhibited the invasion and metastasis of cancer cells by arresting them at the G2/M stage and that it is a likely consequence of the accumulation of an inactive phosphorylated form of Cdk1, caused by the lack of Cdc25 phosphatase activity [21].…”
Section: Discussionmentioning
confidence: 99%
“…These results are in good agreement with the reported analogous ruthenium complexes. [33] The results obtained from absorption spectra are comparable to those obtained from emission binding constants: both sets of binding constants show that complex 1 binds to DNA more avidly than complex 2.…”
Section: Fluorescence Studiesmentioning
confidence: 51%
“…These results suggest that the complex induces apoptosis in HeLa cells, but this activity is only moderate when compared to analogous ruthenium(II) polypyridyl complexes. [11,14,33] …”
Section: Apoptosis Studymentioning
confidence: 99%
“…The blue-fluorescent Hoechst 33342 stained the condensed chromatin of apoptotic cells more brightly than the looser chromatin of normal cells. Nuclei with chromatin condensed at the nuclear margin or in the center of the nucleus as well as fragmented nuclei were classified as apoptotic [14].…”
Section: Apoptosis Detectionmentioning
confidence: 99%