Synthesis ,Characterisation And Anti Cancerus Studies of Schiff Base Complexes of Co(II),Cu(II) And Ni(II) Using DFMPM And L-Histidine

Abstract

Cardanol a naturally occurring C 15 unsaturated aliphatic chain substituted phenol derived from cashew nut shell liquid (CNSL) was used for the preparation of Schiff base ligand using Histidine. di-α-formylmethoxybis (3-pentadecenylphenyl) methane is prepared from cardanol using standard methods. The Schiff base complexes Cu(II), Co(II) and Ni(II) of DFMPM and Histidine were synthesized in three stages . The ligand and complexes were characterized by IR, UV-visible, 1 HNMR and elemental analysis, melting point, metal ion intake, SEM, XRD antibacterial, antifungal, anticancerus, DNA clevage and anti inflammatory activities were studied. The conductance measurements indicate that all the complexes are of non-electrolytes. The result indicate that the complexes of Cu(II), Co(II) and Ni(II) are hexa co-ordinated and have moderate antibacterial, antifungal activity anti cancer, DNA cleavage, larvacidal and anti inflammatory. The metal ion intake indicates the ligand can be used for the removal of these metals from water.