Synthesis, Characterisation and Anticancer Activity of Schiff Base Derivatives of 5-(2-Phenoxypyridin-3-Yl)-1, 3, 4-Thiadiazol-2-Amine

Abstract

Schiff Bases of 5-(2-phenoxypyridin-3-yl)-1, 3, 4-thiadiazol-2-aminederivatives 6(a-h) have been synthesized with different aromatic aldehyde and tested for in vitro anticancer activity; the 1, 3, 4-thiadiazole derivatives were prepared by the reaction ofthiosemicarbazide, phosphorousoxychloride and aromatic acids. The synthesized final Schiff base compounds were purified by column-chromatography and the structures of the titled Schiff bases were elucidated by IR, 1 H NMR and LCMS spectral measurements. Three different cell lines namely Hela, Hep-G2 and MCF7 are used for the present study. The compounds tested were, in most of cases shows cytotoxic effect but, only one compound showed good activity on breast carcinoma cell line having IC50 = 2.28 μg/ mL.

Hybrid MOFs Supercapacitor: A Mini Review

“…This is because the sun does not shine for ever and neither does the wind blow for ever. Electrochemical methods like batteries, fuel cell and supercapacitors are the recognised most potent, efficient and reliable energy storage technologies [1][2][3][4][5][6][7][8][9][10][11][12]. Among these, Supercapacitors also called as ultracapacitors or electrochemical capacitors are most promising and have significant application prospects due to their enhanced power density facilitated by its rapid rate of charging and discharging, performance stability even after large number of charging-discharging cycles, broad temperature range of functionality, low cost of maintenance and ease of use.…”