Synthesis, characterisation and antimicrobial studies of organotin(IV) complexes with 1,10-phenanthroline derivatives

Abstract

a b s t r a c tThe synthesis of several diorganotin(IV) dicarboxylate compounds, including acetates and nicotinates as well as diorganotin(IV) dichloride complexes of the ligands phen, dione and dppz were undertaken. Several difficulties in either the syntheses or complexation reactions with the organic ligands were encountered. The diorganotin(IV) dichloride complexes of the ligands (R 2 SnCl 2 ÁL where R = Me, n-Bu or Ph and L = phen, dione or dppz) were tested against Escherichia coli, Staphylococcus aureus and Pseudomonas aeruginosa. The dibutyltin(IV) derivatives exhibited the broadest range of activity in comparison to the dimethyltin(IV) or diphenyltin(IV) derivatives. The addition of the nicotinate group did not promote activity against any of the bacteria. Furthermore, only in the case of Ph 2 SnCl 2 Ádione was there improved activity compared to the organic ligand itself.

Structure–reactivity studies of chloro and isothiocyanato diorganotin (IV) complexes based on multidentate N‐donor ligands: Synthesis, spectral characterization and crystal structures

“…One of the most impressive bidentate ligands is 1,10‐phenanthroline and its derivatives such as 4,7‐diphenyl‐1,10‐phenanthroline, 1,10‐phenanthroline‐5,6‐dione, dipyridophenazine, 5‐X‐1,10‐phenanthroline (X = Me, NO 2 , Cl) and 5,6‐dimethyl‐1,10‐phenanthroline. A variety of hexa‐coordinated tin (IV) complexes have been synthesized by the reaction of [SnR 2 X 2 ] (R = Me, Et, n Bu, Ph; X = Cl, NCS) with chelating 1,10‐phenanthroline ligand and its derivatives …”