Synthesis, characterisation and phase transition behaviour of temperature-responsive physically crosslinked poly (N-vinylcaprolactam) based polymers for biomedical applications

Halligan, Shane; Dalton, Maurice; Murray, Kieran A.; Dong, Yixiao; Wang, Wenxian; Lyons, John G.; Geever, Luke M.

doi:10.1016/j.msec.2017.03.241

Cited by 49 publications

(31 citation statements)

References 42 publications

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“…From the NVCL monomer spectrum, amide group (C=O) at 1624 cm -1 was detected and C-C observed at 1430 cm -1 was presented to the aliphatic group in the caprolactam ring. Moreover, a further characteristic of C=C peak appeared at 1648 cm -1 and C-H stretching band was observed at 3108 cm -1 in correspondence with studies by Lee et al and Halligan et al [8,34].…”

Section: ■ Results and Discussionsupporting

confidence: 89%

Thermal and Structure Analysis Based on Exfoliation of Clay in Thermosensitive Polymer by <i>in-situ</i> Polymerization

2019

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Poly(N-vinylcaprolactam) (PNVCL) offers superior characteristics as a thermoresponsive polymer for various potential applications. An attractive procedure, namely in-situ polymerization, was used to prepare NVCL/clay nanocomposite in different clay ratios. Organo-modified clay as C20 and B30 were employed in a range between 1–5% based on weight. Thermogravimetric analysis (TGA) and Fourier transform infrared spectroscopy (FTIR) were used to study thermal decomposition and to assess bond conversion during polymerization of the nanocomposite. This research was conducted to study PNVCL characteristics with the addition of clay as a nanocomposite. The stretch mode of the carboxylic group (C=O) and (C=C) was present in the band range about ~1635 cm–1 for the C20, but it was ranging between 1640 to 1664 cm–1 for the B30 of the nanocomposite. It was observed that the decomposition was different for each type of organoclay and the temperature peaked at 30 to 800 °C, to measure the degradation points at 5, 10, and 50%. Comparison results for FTIR and TGA showed that the best nanocomposite was found in the C20 (3%) case.

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Section: ■ Results and Discussionsupporting

confidence: 89%

Thermal and Structure Analysis Based on Exfoliation of Clay in Thermosensitive Polymer by <i>in-situ</i> Polymerization

2019

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“…The PNVCL─VAc spectra exhibited a band around ∼1731 cm −1 , which corresponds to the CO (Figure ) stretching of the aliphatic ester group of VAc . As illustrated in Figure , it was noted that there is a decrease in the intensity of the CO.…”

Section: Resultsmentioning

confidence: 87%

“…These polymers were synthesized via physical crosslinking using a UV curing system (Dr Gröbel UV‐Electronik GmbH) according to the previously reported procedure. This particular irradiation chamber is a controlled radiation source with 20 UV‐tubes that provide a spectral range of between 315 and 400 nm (UV‐A radiation) at an average intensity of 10–13.5 mW/cm 2 . The solutions were pipetted into silicone molds that contained disc and dumbbell specimen impressions.…”

Section: Methodsmentioning

confidence: 99%

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Enhancing and controlling the critical attributes of poly (N‐vinylcaprolactam) through electron beam irradiation for biomedical applications

Halligan

Murray²,

Hopkins

et al. 2019

J of Applied Polymer Sci

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The primary aim of this body of work is to investigate the effect of an industrial scale electron beam sterilization process on novel PNVCL-based smart polymers. There is limited literature available that examines the effects of modifying PNVCL by electron beam irradiation, and as a means of potentially enhancing properties such as the lower critical solution temperature and mechanical behavior. Physically crosslinked poly(N-vinylcaprolactam)-vinyl acetate (PNVCL-VAc) copolymers were prepared by photopolymerization and were subsequently exposed to ionizing radiation via electron beam technology. The mechanical characteristics and phase transitions of the physically crosslinked PNVCL samples were tailored by controlling the electron beam irradiation dose. Importantly, PNVCL and PNVCL-VAc samples (5 wt % in solution) underwent a phase transition between 33.5 and 26.5 C, following electron beam irradiation. Furthermore, all samples displayed a Young's modulus between 1024.3 and 1516.4 MPa depending on the addition of copolymer and electron beam irradiation dose. The industrial scale electron beam sterilization process proved successful in enhancing/modifying many key smart polymer properties, and this ability to formulate and sterilize in one step could prove a very attractive approach for many biomedical applications.

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“…While only a few examples of DOCs have been highlighted in detail herewith, there is tremendous interest and science output of design of new responsive polymeric matrices architectures with unique multi-responsivities useful for many applications, particularly drug delivery and sensing. The work of Zheng et al, 2017 [46], Halligan et al, 2017 [47], de Baubigny et al, 2017 [48], Liu et al, 2017 [49], Thonyot et al, 2017 [50], Nikjoo et al, 2017 [51] and Chacón et al, 2017 [52] are especially interesting in their design of responsive polymer 3DOCs.…”

Section: Sensing Applicationsmentioning

confidence: 99%

Stimuli Responsive Polymer-Based 3D Optical Crystals for Sensing

2017

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3D optical crystals have found their applications in sensing, actuation, optical devices, batteries, supercapacitors, etc. The 3D optical crystal devices are comprised of two main components: colloidal gels and nanoparticles. Nanoparticles self-assemble into face center cubic structures in colloidal gels. The inherent 3D optical crystal structure leads to display of structural colors on these devices following light impingement. As such, these optical properties have led to the utilization of these 3D optical crystals as self-reporting colorimetric sensors, which is the focus of this review paper. While there is extensive work done so far on these materials to exhaustively be covered in this review, we focus here in on: mechanism of color display, materials and preparation of 3D optical crystals, introduction of recent sensing examples, and combination of 3D optical crystals with molecular imprinting technology. The aim of this review is to familiarize the reader with recent developments in the area and to encourage further research in this field to overcome some of its challenges as well as to inspire creative innovations of these materials.

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Synthesis, characterisation and phase transition behaviour of temperature-responsive physically crosslinked poly (N-vinylcaprolactam) based polymers for biomedical applications

Cited by 49 publications

References 42 publications

Thermal and Structure Analysis Based on Exfoliation of Clay in Thermosensitive Polymer by <i>in-situ</i> Polymerization

Thermal and Structure Analysis Based on Exfoliation of Clay in Thermosensitive Polymer by <i>in-situ</i> Polymerization

Enhancing and controlling the critical attributes of poly (N‐vinylcaprolactam) through electron beam irradiation for biomedical applications

Stimuli Responsive Polymer-Based 3D Optical Crystals for Sensing

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