Synthesis, characterisation, molecular docking, biomolecular interaction and cytotoxicity studies of novel ruthenium(<scp>ii</scp>)–arene-2-heteroarylbenzoxazole complexes

De, Sourav; Chaudhuri, Shreya Ray; Panda, Arpita; Jadhav, Gajanan Rahosaheb; Kumar, Rajender; Manohar, Prasanth; Ramesh, Naveen; Mondal, Ashaparna; Moorthy, Anbalagan; Banerjee, Subhasis; Paira, Priyankar; Kumar, Sanjeev

doi:10.1039/c8nj04999h

Cited by 37 publications

(12 citation statements)

References 74 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This also facilitates the selective transport of the drug into cancer cells over normal cells. 63 Molecular-docking studies Interactions with B-DNA dodecamer. The experimental results obtained from spectroscopic studies reveal that the synthesized compounds interact through an intercalative mechanism.…”

Section: In Vitro Cytotoxicity Studiesmentioning

confidence: 99%

Copper(ii) salen-based complexes as potential anticancer agents

et al. 2022

View full text Add to dashboard Cite

show abstract

Section: In Vitro Cytotoxicity Studiesmentioning

confidence: 99%

Copper(ii) salen-based complexes as potential anticancer agents

et al. 2022

View full text Add to dashboard Cite

show abstract

“…[ 2‐3 ] As a consequence, the combination of these two structural features within a single framework giving novel quinolone‐oxazoles has potential for biological and pharmacological activities. [ 4 ] In addition, the extend π structure of these compounds also has potential fluorescence properties to expedite their applications in material science as ligands and chemosensors. To date, only one method has been reported for the synthesis of 2‐(quinolin‐2‐yl)oxazoles based on the cross‐dehydrogenative coupling of quinoline N ‐oxides with 1,3‐azoles (Scheme 1a).…”

Section: Background and Originality Contentmentioning

confidence: 99%

Rh‐Catalyzed Formal [3+2] Cyclization for the Synthesis of 5‐Aryl‐2‐(quinolin‐2‐yl)oxazoles and Its Applications in Metal Ions Probes

Zhou

Zuo

et al. 2021

Chin. J. Chem.

View full text Add to dashboard Cite

Main observation and conclusion A facile and efficient strategy for the synthesis of 5‐aryl‐2‐(quinolin‐2‐yl)oxazoles via rhodium‐catalyzed formal [3+2] cyclization of 4‐aryl‐1‐tosyl‐1H‐1,2,3‐triazoles with quinoline‐2‐carbaldehydes has been described. The protocol employs mild conditions and offers good yields of diverse 2,5‐aryloxazole derivatives with a broad reaction scope. It is amenable to gram‐scale synthesis and easily transformation. Moreover, this 5‐aryl‐2‐(quinolin‐2‐yl)oxazole skeleton is indeed a new fluorophore and its applications in metal ions probes are also investigated and showed fluorescent responses to mercury ion.

show abstract

“…A number of Ru(II) complexes bearing π-bonded arene ligands exhibit promising anticancer activities [77]. De and team [78] have prepared 4 Ru(II)-arene-2-pyridinylbenzoxazole complexes ( Fig. 42) and characterized.…”

Section: Benzoxazole-metal Complexesmentioning

confidence: 99%

Anticancer activity of benzoxazole derivative (2015 onwards): a review

Ghoshal

Patel

2020

Futur J Pharm Sci

View full text Add to dashboard Cite

Background According to the report published recently by the World Health Organization, the number of cancer cases in the world will increase to 22 million by 2030. So the anticancer drug research and development is taking place in the direction where the new entities are developed which are low in toxicity and are with improved activity. Benzoxazole and its derivative represent a very important class of heterocyclic compounds, which have a diverse therapeutic area. Recently, many active compounds synthesized are very effective; natural products isolated with benzoxazole moiety have also shown to be potent towards cancer. Main text In the last few years, many research groups have designed and developed many novel compounds with benzoxazole as their backbone and checked their anticancer activity. In the review article, the recent developments (mostly after 2015) made in the direction of design and synthesis of new scaffolds with very potent anticancer activity are briefly described. The effect of various heterocycles attached to the benzoxazole and their effect on the anticancer activity are thoroughly studied and recorded in the review. Conclusion These compiled data in the article will surely update the scientific community with the recent development in this area and will provide direction for further research in this area.

show abstract

Synthesis, characterisation, molecular docking, biomolecular interaction and cytotoxicity studies of novel ruthenium(ii)–arene-2-heteroarylbenzoxazole complexes

Abstract: Ru(ii)–arene-2-heteroarylbenzoxazole complexes were synthesized and implemented for their biological evaluation.

Cited by 37 publications

References 74 publications

Copper(ii) salen-based complexes as potential anticancer agents

Copper(ii) salen-based complexes as potential anticancer agents

Rh‐Catalyzed Formal [3+2] Cyclization for the Synthesis of 5‐Aryl‐2‐(quinolin‐2‐yl)oxazoles and Its Applications in Metal Ions Probes

Anticancer activity of benzoxazole derivative (2015 onwards): a review

Contact Info

Product

Resources

About