Synthesis, Characterization and Antibacterial Activity of 1,4-di[ aminomethylene carboxyl] phenylene (H2L) and its Complexes Co(II), Cu (II), Zn(II) and Cd (II)

Abstract

Abstract.A binucleating tetradentate Schiff base ligand, 1,4-di[amino methylene carboxylic] phenylene (H2L) and its forth new binuclear complexes [Co(II) , Cu(II) ,Zn(II) and Cd(II)] were prepared via reaction metal (II) chloride with ligand (H2L) using 2:1 (M:L) in ethanol solvent. The new ligand (H2L) and its complexes were characterized by elemental microanalysis (C.H.N), atomic absorption, chloride content, molar conductance's magnetic susceptibility, FTIR UV-Vis spectral and, 1 H, 13 C-NMR (for H2L). The antibacterial activity with bacteria activity with bacteria, Staphylococcus aureus, Bacillus and Esccherichia Coli were studied. IntroductionSchiff base and their metal complexes play an important role in the development of coordination chemistry, resulting in an enormous number of publication, Mohalakshmi and Rajavel have been synthesized [M2(L)]X type (M(II) = Cu, Ni, VO] X= ClO4, SO4 -2 , L = Schiff base derived from 2-Carboxybenzaldehde and 3,3˜,4,4˜-teraaminobiphenyl . They found to be higher antibacterial activity than the free ligand [1]. Bis (O-vaniline) benzidine and its complexes (M (II) = Cu, Co, Mn, Zn) and Sm (III), VO2(VI) have been synthesized with 3D molecular modeling and analysis for bond lengths and bond angles have also been carried out on Ni-complex [2]. Metal complexes of Schiff bases derived from substituted salicylaldehydes and various amines have been widely investigated because of their applicability. Chelating ligands containg O and N donor atoms show broad biological activity and are special interest because of the variety of ways in which they are bonded metal ions [2,[3][4][5][6][7][8]. It is well known Schiff bases complexes have numerous applications, such as in the treatment cancer [9], as antibactericide agents and as antifungicide agents [10,11]. Recently one of our group research has studied mixed ligand (1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1 H-pyrazol-4-ylimino) and azide ion forming complexes with Mn(II), Co(II), Ni(II), Zn(II), Cd(II) and Hg(II) ion [12].Mononuclear complexes [L.M.XH2O], L=[-2-Carboxy methylene amino]phenylimino] acetic acid and, [LM.XH2O]Cl L= pyrimidine-2-ylimino acetic acid with M(II) = Co, Ni, Cu, Cd, Hg and Pb were prepared too [13,14]. This paper described the synthesis spectral and magnetic studies of Schiff base 1,4-di-[amino methylene carboxy] phenylene (H2L) and its binuclear M(II) = Cu, Co, Zn, and Cd complexes. Indeed, the biological activity of the ligand (H2L) and its complexes are screened against selected kinds of bacteria Bacillus cereus, Staphylococcus aureus and E.Coli.