There is an urgent need to develop a series of multifunctional materials with good biocompatibility, high mechanical strength, hemostatic properties, anti‐adhesion, and anti‐infection for applications in wound care. However, successfully developing multifunctional materials is challenging. In this study, two superhydrophobic composite coatings with good biocompatibility, high mechanical strength, strong antifouling and blood repellency, fast hemostasis, and good antibacterial activity were prepared on cotton fabric surface by simple, green, and low‐cost one‐step dip‐coating technology. The results discussed in the manuscript revealed that the two superhydrophobic composite coatings could maintain good mechanical stability, strong water repellency, and durability under various types of mechanical damage, high‐temperature treatment, and long‐term strong light irradiation. The coatings also exhibited good repellency to various solid pollutants, highly viscous liquid pollutants and blood. In vitro and in vivo hemostatic experiments showed that both composite coatings had good hemostatic and anti‐clot adhesion properties. More importantly, this superhydrophobic coating prevented bacterial adhesion and growth and released Cu2+ and Zn2+ ions and chitosan to achieve bactericidal properties, thereby protecting injured skin from bacterial infection. The two superhydrophobic coatings enhanced the anti‐fouling, anti‐adhesion, hemostatic, and antibacterial functions of blood‐repellent dressings and therefore have broad application prospects in medical and textile fields.This article is protected by copyright. All rights reserved