Synthesis, characterization, and anticancer activity of two mixed ligand copper(ii) complexes by regulating the VEGF/VEGFR2 signaling pathway

Abstract

The single crystals of two novel mixed-ligand copper(ii)-based complexes were obtained and characterized. These complexes can remarkably induce apoptosis, inhibit proliferation, suppress migration and metastasis, and inhibit angiogenesis to inhibit the growth of cervical cancer by down-regulating the expressions of the important proteins FAK, Akt and Erk1/2 or their phosphorylated proteins p-FAK, p-Akt, and p-Erk1/2 downstream of the VEGF/VEGFR2 signaling pathway.

Tetranuclear Cu(ii)-chiral complexes: synthesis, characterization and biological activity

“…In R-1, the unidentate ligand coordinating to Cu1 is not pure methanol, but a disordered superposition of methanol (70%) and water (30%). This disordered mixture inuences the position of the neighbouring nitrate since through the presence of coordinated H 2 O, the (7) À0.003 (15) nitrate is pulled closer to the core structure than in methanol case. The FTIR spectra in the region 4000-400 cm À1 for complexes S-1 and R-1 have been evaluated ( Fig.…”

“…[9][10][11][12] Recent studies reveal that the use of novel Schiff-base copper(II)based complexes can remarkably induce apoptosis, inhibit proliferation, suppress migration, metastasis and angiogenesis and thus inhibit the growth of cervical cancer. [13][14][15][16][17][18][19][20][21][22] Schiff-base ligand derivatives have been widely used in coordination chemistry due to the advantages of their exible properties and the easy manipulation of their coordination properties via the variation of functional groups such as amine, alcohol, carboxylate and sulfonate. [23][24][25][26] Out of the small number of Cu(II) complexes formed with pocket ligands only one of these employs a chiral ligand and none contain Cu(II) coordination clusters.…”

Synthesis, characterization and anticancer activity of new 2-acetyl-5-methyl thiophene and cinnamaldehyde thiosemicarbazones and their palladium(II) complexes

“…The chemistry of transition metal complexes of thiosemicarbazone (TSC) ligands has attracted a lot of research interests due to the numerous pharmacological properties portrayed by both the ligands and the complexes [1]. The excellent chelating property of TSCs has been an attractive feature in coordination chemistry hence the vast interest in their chemistry for a span of six decades [2][3][4]. The TSCs are a class of N, S bidentate Schiff base ligands which are generally synthesized by the condensation of a ketone or an aldehyde with a thiosemicarbazide under suitable reaction conditions.…”

Epithelial–mesenchymal transition and metastasis of colon cancer cells induced by the FAK pathway in cancer-associated fibroblasts

“…17 Copper can bind directly to angiogenin to enhance its activity. [17][18][19] Copper may also affect cancer cell invasion of surrounding tissues or transfer to distant organs. Herein, lysine oxidase contributes to the remodeling of the extracellular matrix and the establishment of the microenvironment at the metastasis site, and its activity is dependent on copper.…”