Synthesis, Characterization and Anticancer Activity of Some Benzothiazole and Thiazole Derivatives

Abstract

Objective: This study aimed synthesis of benzothiazole and thiazole derivatives due to the importance of these heterocycles as anticancer. Method: Novel benzothiazole and thiazole derivatives 2-40 were synthesized through different chemical reactions. Results: Structures of these compounds were confirmed by spectral and elemental analyses. The obtained compounds were evaluated for their in vitro antitumor activity against 60 human cancer cell lines by the National Cancer Institute (NCI). Conclusion: Twelve compounds 4

Design, synthesis, and antitumor screening of new thiazole, thiazolopyrimidine, and thiazolotriazine derivatives as potent inhibitors of VEGFR‐2

“…Thiazoles (Ayati et al, 2019; Ewida et al, 2017; Hassan et al, 2020; Pawar et al, 2021; de Santana et al, 2018; Sayed et al, 2020; Sharma et al, 2020) caught the attention of medicinal chemists due to their potential anticancer properties. Thiazole is a crucial scaffold for several antitumor agents targeting VEGFR‐2 (Al‐Warhi et al, 2022; El‐Naggar et al, 2022; Hassan et al, 2021).…”

“…Thiazoles (Ayati et al, 2019;Ewida et al, 2017;Hassan et al, 2020;Pawar et al, 2021;de Santana et al, 2018;Sayed et al, 2020;Sharma et al, 2020) caught the attention of medicinal chemists due to their potential anticancer properties.…”